ArticleProceedings of the National Academy of Sciences of the United States of America2013
Correlations in ion channel expression emerge from homeostatic tuning rules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed.
- Article
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- Computational Advances in Taste Perception: From Ion Channels and Taste Receptors to Neural Coding.Brain sciences · 2025Article
- The electrogenicity of the NaeLife · 2025Article
- Correlative voltage imaging and cryo-electron tomography bridge neuronal activity and molecular structure.Nature communications · 2025Article
- Ionocyte CFTR Coordinates Chloride Absorption and Secretion to Balance Airway Fluid.American journal of respiratory and critical care medicine · 2025Article
- Modeling escalation of drug intake to identify molecular targets for treating substance use disorders: A slippery slope upward.Neuroscience and biobehavioral reviews · 2025Review
- The ion transport, GPCR, and RTK toolkit expression in the human cerebrovascular endothelial cell line, hCMEC/D3: an Omics perspective.Frontiers in physiology · 2025Article
- Dimensionality reduction of neuronal degeneracy reveals two interfering physiological mechanisms.PNAS nexus · 2024Article
- A possible path to persistent re-entry waves at the outlet of the left pulmonary vein.NPJ systems biology and applications · 2024Article
- Do calcium channel blockers applied to cardiomyocytes cause increased channel expression resulting in reduced efficacy?NPJ systems biology and applications · 2024Article
- Article
- Biological complexity facilitates tuning of the neuronal parameter space.PLoS computational biology · 2023Article
- Gating of homeostatic regulation of intrinsic excitability produces cryptic long-term storage of prior perturbations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sodium channel slow inactivation normalizes firing in axons with uneven conductance distributions.Current biology : CB · 2023Article
- Emergent activity, heterogeneity, and robustness in a calcium feedback model of the sinoatrial node.Biophysical journal · 2023Article
- Plasticity manifolds and degeneracy govern circadian oscillations of neuronal intrinsic properties in the suprachiasmatic nucleus.iScience · 2023Article
- Review
56 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Experimental observations reveal that the expression levels of different ion channels vary across neurons of a defined type, even when these neurons exhibit stereotyped electrical properties. However, there are robust correlations between different ion channel expression levels, although the mechanisms that determine these correlations are unknown. Using generic model neurons, we show that correlated conductance expression can emerge from simple homeostatic control mechanisms that couple expression rates of individual conductances to cellular readouts of activity. The correlations depend on the relative rates of expression of different conductances. Thus, variability is consistent with homeostatic regulation and the structure of this variability reveals quantitative relations between regulation dynamics of different conductances. Furthermore, we show that homeostatic regulation is remarkably insensitive to the details that couple the regulation of a given conductance to overall neuronal activity because of degeneracy in the function of multiple conductances and can be robust to "antihomeostatic" regulation of a subset of conductances expressed in a cell.
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