ArticleProceedings of the National Academy of Sciences of the United States of America2013
S-nitrosylation therapy to improve oxygen delivery of banked blood.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
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Who cites it
24 citing papers in PubMed.
- Autologous transfusion of stored red blood cells increases pulmonary artery pressure.American journal of respiratory and critical care medicine · 2014Trial
- Effects of plasma donation on blood rheology and peripheral vascular function.The Journal of physiology · 2026Article
- Simulated Oxygen Supply Efficiency Assessment to Represent Stored Red Blood Cells Quality.Life (Basel, Switzerland) · 2026Article
- Optimizing post brain death vascularized composite graft quality through ex vivo restoration of S-nitrosothiol homeostasis.Scientific reports · 2025Article
- Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo.Thrombosis and haemostasis · 2024Article
- Renal dysfunction in adults following cardiopulmonary bypass is linked to declines in S-nitroso hemoglobin: a case series.Annals of medicine and surgery (2012) · 2024Article
- Control of tissue oxygenation by S-nitrosohemoglobin in human subjects.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The enzymatic function of the honorary enzyme: S-nitrosylation of hemoglobin in physiology and medicine.Molecular aspects of medicine · 2022Review
- Red Blood Cell-Mediated S-Nitrosohemoglobin-Dependent Vasodilation: Lessons Learned from a β-Globin Cys93 Knock-In Mouse.Antioxidants & redox signaling · 2021Review
- Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle.Circulation research · 2020Review
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation.Clinical pharmacology and therapeutics · 2018Article
- S-Nitrosohemoglobin Levels and Patient Outcome After Transfusion During Pediatric Bypass Surgery.Clinical and translational science · 2018Observational
- Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells.Thrombosis and haemostasis · 2017Article
- Mechanical perturbations trigger endothelial nitric oxide synthase activity in human red blood cells.Scientific reports · 2016Article
- Lung Structure and the Intrinsic Challenges of Gas Exchange.Comprehensive Physiology · 2016Review
- Transfused older stored red blood cells improve the clinical course and outcome in a canine lethal hemorrhage and reperfusion model.Transfusion · 2015Article
- Renitrosylation of banked human red blood cells improves deformability and reduces adhesivity.Transfusion · 2015Article
- Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion.American journal of physiology. Heart and circulatory physiology · 2014Article
- Importance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility.Current opinion in pharmacology · 2014Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
From the perspectives of disease transmission and sterility maintenance, the world's blood supplies are generally safe. However, in multiple clinical settings, red blood cell (RBC) transfusions are associated with adverse cardiovascular events and multiorgan injury. Because ∼85 million units of blood are administered worldwide each year, transfusion-related morbidity and mortality is a major public health concern. Blood undergoes multiple biochemical changes during storage, but the relevance of these changes to unfavorable outcomes is unclear. Banked blood shows reduced levels of S-nitrosohemoglobin (SNO-Hb), which in turn impairs the ability of stored RBCs to effect hypoxic vasodilation. We therefore reasoned that transfusion of SNO-Hb-deficient blood may exacerbate, rather than correct, impairments in tissue oxygenation, and that restoration of SNO-Hb levels would improve transfusion efficacy. Notably in mice, administration of banked RBCs decreased skeletal muscle pO2, but infusion of renitrosylated cells maintained tissue oxygenation. In rats, hemorrhage-induced reductions in muscle pO2 were corrected by SNO-Hb-repleted RBCs, but not by control, stored RBCs. In anemic awake sheep, stored renitrosylated, but not control RBCs, produced sustained improvements in O2 delivery; in anesthetized sheep, decrements in hemodynamic status, renal blood flow, and kidney function incurred following transfusion of banked blood were also prevented by renitrosylation. Collectively, our findings lend support to the idea that transfusions may be causally linked to ischemic events and suggest a simple approach to prevention (i.e., SNO-Hb repletion). If these data are replicated in clinical trials, renitrosylation therapy could have significant therapeutic impact on the care of millions of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.