ArticleAmerican journal of perinatology2014
Adrenomedullin signaling pathway polymorphisms and adverse pregnancy outcomes.
Article in American journal of perinatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Complement factor B activation in patients with preeclampsia.Journal of reproductive immunology · 2015Trial
- Effect of magnesium sulfate treatment on mediators of endothelial dysfunction and electrolytes in mild and severe preeclampsia: A case-control study.Health science reports · 2023Article
- Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone.Frontiers in physiology · 2018Article
- Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium.Biology of reproduction · 2017Article
- Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and lamininα1 expressing cells.Reproductive biology · 2016Article
- Adrenomedullin in lymphangiogenesis: from development to disease.Cellular and molecular life sciences : CMLS · 2015Review
- Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development.Developmental cell · 2014Article
- Midregional pro-adrenomedullin plasma concentrations are blunted in severe preeclampsia.Placenta · 2014Article
- Adrenomedullin and endocrine control of immune cells during pregnancy.Cellular & molecular immunology · 2014Review
- Adrenomedullin promotes rat trophoblast stem cell differentiation.Biology of reproduction · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveReduced maternal plasma levels of the peptide vasodilator adrenomedullin have been associated with adverse pregnancy outcomes. We measured the extent to which genetic polymorphisms in the adrenomedullin signaling pathway are associated with birth weight, glycemic regulation, and preeclampsia risk. STUDY
designWe genotyped 1,353 women in the Pregnancy, Infection, and Nutrition Postpartum Study for 37 ancestry-informative markers and for single-nucleotide polymorphisms in adrenomedullin (ADM), complement factor H variant (CFH), and calcitonin receptor-like receptor (CALCRL). We used linear and logistic regression to model the association between genotype and birth weight, glucose loading test (GLT) results, preeclampsia, and gestational diabetes (GDM). All models were adjusted for pregravid body mass index, maternal age, and probability of Yoruban ancestry. p values of < 0.05 were considered statistically significant.
resultsAmong Caucasian women, ADM rs57153895, a proxy for rs11042725, was associated with reduced birth weight z-score. Among African-American women, ADM rs57153895 was associated with increased birth weight z-score. Two CALCRL variants were associated with GDM risk. CFH rs1061170 was associated with higher GLT results and increased preeclampsia risk.
conclusionConsistent with studies of plasma adrenomedullin and adverse pregnancy outcomes, we found associations between variants in the adrenomedullin signaling pathway and birth weight, glycemic regulation, and preeclampsia.
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