Evidence map›Paper›PMID 23797870›Full record

ReviewNature reviews. Gastroenterology & hepatology2013

Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets.

Gary M Mawe, Jill M Hoffman

Erratum issued Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05026333 (Pilot Study Aimed to Determine the Optimal Design for the UCLA/Danone Probiotic Intervention Study Related to Stress), which is not on this map. Cited by 606 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
606citing papers in PubMed, 4 pooled it
23.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05026333 nacompletednot on this mapstarted 2021, after this paper: background citation

Pilot Study Aimed to Determine the Optimal Design for the UCLA/Danone Probiotic Intervention Study Related to Stress

TypeinterventionalSponsorUniversity of California, Los AngelesRan2021 to 2022Enrolled100ConditionsStress, Psychological, AnxietyArmsCognitive Stress Testing
3 · Its place in the literature

Who cites it

606 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
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  12. Review
  13. Article
  14. Applied and environmental microbiology · 2026
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Review

546 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gary M MaweDepartment of Neurological Sciences, D403A Given Building, 89 Beaumont Avenue, University of Vermont, Burlington, VT 05405, USA. gary.mawe@uvm.edu
Jill M Hoffman
University of California, Los Angeles · USUniversity of Vermont · US

Funding

Neuronal Excitability and Motility in ColitisR01DK062267 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI MAWE, GARY M · 2002 to 2016
$3.3M
NIDDK NIH HHS DK62267NIDDK NIH HHS R01 DK062267
6 · The paper itself

Abstract

Serotonin (5-HT) has been recognized for decades as an important signalling molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT continue to be discovered, as well as distant actions of gut-derived 5-HT, and we are learning how 5-HT signalling is altered in gastrointestinal disorders. Conventional functions of 5-HT involving intrinsic reflexes include stimulation of propulsive and segmentation motility patterns, epithelial secretion and vasodilation. Activation of extrinsic vagal and spinal afferent fibres results in slowed gastric emptying, pancreatic secretion, satiation, pain and discomfort, as well as nausea and vomiting. Within the gut, 5-HT also exerts nonconventional actions such as promoting inflammation and serving as a trophic factor to promote the development and maintenance of neurons and interstitial cells of Cajal. Platelet 5-HT, originating in the gut, promotes haemostasis, influences bone development and serves many other functions. 5-HT3 receptor antagonists and 5-HT4 receptor agonists have been used to treat functional disorders with diarrhoea or constipation, respectively, and the synthetic enzyme tryptophan hydroxylase has also been targeted. Emerging evidence suggests that exploiting epithelial targets with nonabsorbable serotonergic agents could provide safe and effective therapies. We provide an overview of these serotonergic actions and treatment strategies.

Indexed as

Enteric Nervous SystemGastrointestinal DiseasesGastrointestinal MotilityGastrointestinal TractHumansSerotoninSerotonin AgentsSignal TransductionSerotoninSerotonin Agents

Identifiers

PMID23797870
PMCPMC4048923
OpenAlexW2085139899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.