ArticleNature reviews. Endocrinology2013
Testosterone and insulin resistance in the metabolic syndrome and T2DM in men.
Article in Nature reviews. Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 1 synthesis or guideline pooled it, 282 citations in OpenAlex.
- Effect of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Male Sexual Function: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Leptin levels are associated with coronary artery calcification in patients with advanced prostate cancer.The oncologist · 2025Trial
- Trial
- The effects of a low carbohydrate diet on erectile function and serum testosterone levels in hypogonadal men with metabolic syndrome: a randomized clinical trial.BMC endocrine disorders · 2023Trial
- Antioxidant Efficacy of a Standardized Red Orange (Nutrients · 2022Trial
- Effects of short-term sex steroid suppression on dietary fat storage patterns in healthy males.Physiological reports · 2018Trial
- Trial
- Associations between diet quality and testosterone: evidence from mixture and mediation analysis.International urology and nephrology · 2026Article
- Update on testosterone deficiency and therapeutic options for testosterone replacement therapy.Nature reviews. Urology · 2026Review
- Beyond metabolic control: the potential role of antidiabetic therapies in modulating male reproductive function and spermatogenesis.Reviews in endocrine & metabolic disorders · 2026Review
- Article
- Erectile dysfunction and cardiovascular health.Nature reviews. Urology · 2026Review
- The Serum Testosterone Level in Male Patients Is Inversely Associated With Hypertension Incidence.Journal of clinical hypertension (Greenwich, Conn.) · 2026Observational
- Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.International journal of molecular sciences · 2026Review
- The mediating role of testosterone in the relationship between body fat percentage and diabetes mellitus risk.Frontiers in endocrinology · 2026Article
- Article
- Association between circulating sex hormone levels and diabetic kidney disease in men and postmenopausal women with type 2 diabetes mellitus.World journal of diabetes · 2025Article
- Association between estimated glucose disposal rate and testosterone deficiency in male patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Estimated Glucose Disposal Rate and Risk of Stroke and Dementia in Nondiabetics: A UK Biobank Prospective Cohort Study.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Association Between Dietary Intake of Omega-3 Fatty Acids and Serum Testosterone in Adult Males: Results From NHANES 2011-2016 and 2021-2023.Food science & nutrition · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity, type 2 diabetes mellitus and the metabolic syndrome are major risk factors for cardiovascular disease. Studies have demonstrated an association between low levels of testosterone and the above insulin-resistant states, with a prevalence of hypogonadism of up to 50% in men with type 2 diabetes mellitus. Low levels of testosterone are also associated with an increased risk of all-cause and cardiovascular mortality. Hypogonadism and obesity share a bidirectional relationship as a result of the complex interplay between adipocytokines, proinflammatory cytokines and hypothalamic hormones that control the pituitary-testicular axis. Interventional studies have shown beneficial effects of testosterone on components of the metabolic syndrome, type 2 diabetes mellitus and other cardiovascular risk factors, including insulin resistance and high levels of cholesterol. Biochemical evidence indicates that testosterone is involved in promoting glucose utilization by stimulating glucose uptake, glycolysis and mitochondrial oxidative phosphorylation. Testosterone is also involved in lipid homeostasis in major insulin-responsive target tissues, such as liver, adipose tissue and skeletal muscle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.