ArticleScientific reports2013
Computational microscopy of cyclodextrin mediated cholesterol extraction from lipid model membranes.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Amyloid β-Cholesterol Interplay: Removal of Cholesterol From the Membranes to Catalyze Aggregation and Amyloid Pathology.Journal of neurochemistry · 2026Article
- Cyclodextrin-Based Formulations as a Promising Strategy to Overcome the Blood-Brain Barrier: Historical Overview and Prospects in Glioblastoma Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Cyclodextrins: Establishing building blocks for AI-driven drug design by determining affinity constantsComputational and structural biotechnology journal · 2024Article
- The interaction of a self-assembled nanoparticle and a lipid membrane: Binding, disassembly and re-distribution.Heliyon · 2024Article
- Cyclodextrin-Containing Drug Delivery Systems and Their Applications in Neurodegenerative Disorders.International journal of molecular sciences · 2024Review
- Review
- Addition of low concentration of cholesterol-loaded cyclodextrin (CLC) has a positive effect on cryopreserved canine spermatozoa evaluated by andrological and biophysical methods.BMC veterinary research · 2024Article
- Problems of human spermatozoa cryopreservation: research methods, solutions.Biophysical reviews · 2023Review
- CHARMM-GUIJournal of chemical theory and computation · 2023Review
- Solid-State Formation of a Potential Melphalan Delivery Nanosystem Based on β-Cyclodextrin and Silver Nanoparticles.International journal of molecular sciences · 2023Article
- Martini 3 Coarse-Grained Force Field for Carbohydrates.Journal of chemical theory and computation · 2022Article
- Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?Pharmaceutics · 2022Review
- Extending the Martini 3 Coarse-Grained Force Field to Carbohydrates.Journal of chemical theory and computation · 2022Article
- Sterol Extraction from Isolated Plant Plasma Membrane Vesicles Affects HBiomolecules · 2021Article
- Measurement of Single-Molecule Forces in Cholesterol and Cyclodextrin Host-Guest Complexes.The journal of physical chemistry. B · 2021Article
- Application of Molecular Dynamics Simulations in the Analysis of Cyclodextrin Complexes.International journal of molecular sciences · 2021Review
- A mathematical model of the role of aggregation in sonic hedgehog signalling.PLoS computational biology · 2021Article
- The Sterol Trafficking Pathway inFrontiers in plant science · 2021Article
- Article
- The Budesonide-Hydroxypropyl-β-Cyclodextrin Complex Attenuates ROS Generation, IL-8 Release and Cell Death Induced by Oxidant and Inflammatory Stress. Study on A549 and A-THP-1 Cells.Molecules (Basel, Switzerland) · 2020Article
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3 authors.
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Abstract
Beta-cyclodextrins (β-CDs) can form inclusion complexes with cholesterol, and are commonly used to manipulate cholesterol levels of biomembranes. In this work, we have used multiscale molecular dynamics simulations to provide a detailed view on the interaction between β-CDs and lipid model membranes. We show that cholesterol can be extracted efficiently upon adsorption of β-CD dimers at the membrane/water interface. However, extraction is only observed to occur spontaneously in membranes with high cholesterol levels. Free energy calculations reveal the presence of a kinetic barrier for cholesterol extraction in the case of low cholesterol content. Cholesterol uptake is facilitated in case of (poly)unsaturated lipid membranes, which increases the free energy of the membrane bound state of cholesterol. Comparing lipid/cholesterol compositions typical of liquid-disordered (L(d)) and liquid-order (L(o)) domains, we furthermore show that cholesterol is preferentially extracted from the disordered regions, in line with recent experimental data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.