ArticleMedical oncology (Northwood, London, England)2013
Co-expression of AQP3 and AQP5 in esophageal squamous cell carcinoma correlates with aggressive tumor progression and poor prognosis.
Article in Medical oncology (Northwood, London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Expression of aquaporin 3 in squamous cell carcinoma in dogs and cats.The Journal of veterinary medical science · 2026Article
- Comprehensive Immunophenotypic Profiling and Prognostic Value in Salivary Gland Mucoepidermoid Carcinoma.International dental journal · 2026Article
- Uncovering the role of aquaporin and chromobox family members as potential biomarkers in head and neck squamous cell carcinoma via integrative multiomics and in silico approach.Journal of applied genetics · 2024Article
- Pathophysiological role of ion channels and transporters in hepatocellular carcinoma.Cancer gene therapy · 2024Review
- Aquaporin-mediated dysregulation of cell migration in disease states.Cellular and molecular life sciences : CMLS · 2023Review
- Aquaporins as Prognostic Biomarker in Prostate Cancer.Cancers · 2023Review
- Review
- Pathophysiological role of ion channels and transporters in HER2-positive breast cancer.Cancer gene therapy · 2022Review
- Effects of a Chinese herbal extract on the intestinal tract and aquaporin in Adriamycin-induced nephropathy.Bioengineered · 2022Article
- Effect of differential hypoxia-related gene expression on glioblastoma.The Journal of international medical research · 2021Article
- Deciphering the structure, function, expression and regulation of aquaporin-5 in cancer evolution.Oncology letters · 2021Review
- Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases.Frontiers in genetics · 2021Review
- Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury.Nature communications · 2020Article
- Article
- Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets.Pathology oncology research : POR · 2020Review
- Aquaporin 5 promotes tumor migration and angiogenesis in non-small cell lung cancer cell line H1299.Oncology letters · 2020Article
- Aquaporin 1, 3, and 5 Patterns in Salivary Gland Mucoepidermoid Carcinoma: Expression in Surgical Specimens and an In Vitro Pilot Study.International journal of molecular sciences · 2020Article
- Hypoxia-Induced Aquaporin-3 Changes Hepatocellular Carcinoma Cell Sensitivity to Sorafenib by Activating the PI3K/Akt Signaling Pathway.Cancer management and research · 2020Article
- Peroxiporins in Cancer.International journal of molecular sciences · 2019Review
- Expression of AQP3 and AQP5 as a prognostic marker in triple-negative breast cancer.Oncology letters · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the expression patterns of aquaporin 3 (AQP) 3 and AQP5, to evaluate their relationships with clinicopathological characteristics, and to determine their correlations with survival in esophageal squamous cell carcinoma (ESCC) patients, expression levels of AQP3 and AQP5 proteins in 126 ESCC patients were detected by immunohistochemistry. Then, paired Student's t-test, chi-square test, Spearman's rank correlation, Kaplan-Meier plots, and Cox proportional hazards regression model were used to analyze their associations with clinicopathological characteristics and survivals of ESCC patients. Both AQP3 and AQP5 proteins were localized on the cell membrane of tumor cells in ESCC tissues. The expression levels of two proteins in ESCC tissues were significantly higher than those in adjacent normal tissues (both P < 0.001). Additionally, high expression of AQP3 and AQP5 was both correlated with advanced invasion depth (both P = 0.01), aggressive lymph node status (P = 0.02 and 0.01, respectively), and positive distant metastasis (both P = 0.01). However, the overexpression of AQP3 and AQP5 alone did not influence the prognosis. Furthermore, ESCC patients with the co-expression of AQP3 and AQP5 showed the poorest prognosis in overall (P = 0.002) and disease-free survival (P < 0.001). Multivariate analysis showed that the co-expression of AQP3 and AQP5 was an independent prognostic factors of overall (P = 0.01) and disease-free survival (P = 0.01) in ESCC. Our data demonstrate for the first time that high expression of both AQP3 and AQP5, not each alone, is an independent poor prognostic factor in ESCC patients. Combined detection of the two proteins' expression may help to predict the progression and the prognosis of ESCC patients.
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