ArticleJournal of molecular neuroscience : MN2013
The expression of FBP1 after traumatic brain injury and its role in astrocyte proliferation.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Expression of Dixdc1 and its Role in Astrocyte Proliferation after Traumatic Brain Injury.Cellular and molecular neurobiology · 2017Article
- High-mobility group box 1 released from astrocytes promotes the proliferation of cultured neural stem/progenitor cells.International journal of molecular medicine · 2014Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
Far upstream element binding protein 1 (FBP1) has been identified as an upstream gene of p27kip1 (p27), which is a key regulator of mammalian cell cycle regulation and neurogenesis. To elucidate the expression and function of FBP1 in central nervous system lesion and repair, we performed a traumatic brain injury (TBI) model in adult rats. We observed that FBP1 protein level significantly reduced at day 3 after injury, and the downregulation of FBP1 was predominant in astrocytes, which were largely proliferated after injury. Furthermore, in vitro, overexpression of FBP1 was concomitant with the up-regulation of p27 and reduction of PCNA in LPS-induced astrocyte proliferation. These results suggest that a decreased level of FBP1 in brain is involved in the proliferation of glial cells after TBI.
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