Evidence map›Paper›PMID 23797577›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013

A systematic review of health-related quality of life instruments in patients with cancer cachexia.

Sally Wheelwright, Anne-Sophie Darlington, Jane B Hopkinson, Deborah Fitzsimmons, Alice White, Colin D Johnson

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07255001 (Monitoring Physical Function Changes in Patients With Pancreatic Ductal Adenocarcinoma), which is not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07255001 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Monitoring Physical Function Changes in Patients With Pancreatic Ductal Adenocarcinoma: Potential for Better Understanding of Treatment Trajectory and Survival

TypeinterventionalSponsorBritish Columbia Cancer AgencyRan2025 to 2027Enrolled50ConditionsPancreatic Ductal Adenocarcinoma (PDAC), Hand Grip StrengthArmsHand grip strength assessments using a dynamometer
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  5. The quality of systematic reviews of health-related outcome measurement instruments.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016
    Pooled it
  6. Pooled it
  7. Article
  8. Article
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  13. Review
  14. Observational
  15. Clinical and prognostic role of 2-[Annals of hematology · 2022
    Article
  16. Review
  17. Article
  18. Observational
  19. Review
  20. Metabolic Biomarkers for the Early Detection of Cancer Cachexia.Frontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sally WheelwrightCancer Sciences, University of Southampton, Southampton, UK. S.J.Wheelwright@soton.ac.uk
Anne-Sophie Darlington
Jane B Hopkinson
Deborah Fitzsimmons
Alice White
Colin D Johnson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAssessing the health-related quality of life (HRQOL) of cancer patients with cachexia is particularly important because treatments for cachexia are currently aimed at palliation and treatment efficacy must be measured in ways other than survival. The aim of this systematic review was to evaluate HRQOL assessment in cancer patients with cachexia.

methodsUsing guidance from the Centre for Reviews and Dissemination, relevant databases were searched from January 1980 to January 2012 with terms relating to cancer, cachexia and HRQOL for papers including adult cancer patients with cachexia or documented weight loss at baseline.

resultsWe found one cachexia-specific instrument, the Functional Assessment of Anorexia/Cachexia Therapy, but the tool has not been fully validated, does not cover all the relevant domains and the consensus-based standards for the selection of health status measurement instruments checklist highlighted a number of weaknesses in the methodological quality of the validation study. Sixty-seven studies assessed HRQOL in cachectic or weight-losing cancer patients. Most used generic cancer HRQOL instruments, limiting the amount of useful information they provide. A modified version of the Efficace minimum data checklist demonstrated that the quality of reporting on HRQOL tool use was inadequate in many of the studies. A negative relationship between HRQOL and weight loss was found in 23 of the 27 studies which directly examined this.

conclusionThere is a pressing need for a well-designed HRQOL tool for use with this patient group in both clinical trials and clinical practice.

Indexed as

Health StatusQuality of LifeAnorexiaCachexiaHumansNeoplasmsTreatment Outcome

Identifiers

PMID23797577

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.