ArticleJournal of molecular medicine (Berlin, Germany)2013
Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus.
Article in Journal of molecular medicine (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Hyperbaric oxygen therapy to prevent central airway stenosis after lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Trial
- Preservation of bronchial artery circulation on ex-vivo lung perfusion.Scientific reports · 2025Article
- Application of a degradable thin film to modulate perfusion to post-autotransplantation airways in rats.JTCVS open · 2025Article
- Article
- Review
- Airway hypoxia in lung transplantation.Current opinion in physiology · 2019Article
- Iron: an essential nutrient for Aspergillus fumigatus and a fulcrum for pathogenesis.Current opinion in infectious diseases · 2018Review
- Hypoxia Signaling in Vascular Homeostasis.Physiology (Bethesda, Md.) · 2018Review
- Microhemorrhage-associated tissue iron enhances the risk forScience translational medicine · 2018Article
- HIF-1alpha and infectious diseases: a new frontier for the development of new therapies.Revista do Instituto de Medicina Tropical de Sao Paulo · 2017Review
- Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.JCI insight · 2017Review
- Aspergillus-related pulmonary diseases in lung transplantation.Medical mycology · 2017Review
- New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches.Cytokine · 2016Review
- Microvascular injury after lung transplantation.Current opinion in organ transplantation · 2016Review
- Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation.American journal of respiratory and critical care medicine · 2016Article
- Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective.Clinical and experimental immunology · 2016Review
- Kidney injury is independent of endothelial HIF-1α.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Insights into the cellular responses to hypoxia in filamentous fungi.Current genetics · 2015Review
- Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Article
- Graft microvascular disease in solid organ transplantation.Journal of molecular medicine (Berlin, Germany) · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Microvascular ischemia and infections are associated with the development of chronic rejection following lung transplantation. The von Hippel–Lindau protein (VHL) controls protein levels of hypoxia-inducible factors (HIFs), regulates vascular repair, and improves tissue perfusion. Here, we studied the role of VHL in microvascular repair by orthotopically transplanting tracheas into mice with VHL haplodeficiency in Tie2 lineage cells. We showed that VHL haplodeficiency prolonged airway microvascular perfusion and promoted tissue blood flow through the production of the angiogenic factors, SDF-1 and angiopoietin 1. VHL-haplodeficient pulmonary endothelial cells exhibited increased angiogenic activity, resistance to serum deprivation-induced cell death, and enhanced microvascular repair. By contrast, in recipient mice with HIF-1α deficiency in Tie2 lineage cells, microvascular repair was significantly diminished and suggested that recipient-derived HIF-1α normally participates in the repair of alloimmune-mediated microvascular damage. To evaluate the translational impact of our findings, we compared VHL-haplodeficient mice with wild-type controls using a model of Aspergillus airway infection. In 83% of the VHL-haplodeficient recipients, Aspergillus fumigatus was noninvasive in contrast to 75% of wild-type mice in which the mold was deeply invasive. Our study demonstrated that stabilization of HIF-1α in angiogenic cells, through Tie2 cell VHL haplodeficiency, promoted airway microvascular regeneration and vascular normalization and thereby minimized tissue ischemia and hypoxia. By also mitigating the virulence of A. fumigatus, a common pathogen and itself a risk factor for the development of lung transplant rejection, the selective enhancement of HIF-1α expression has the prospect of offering several novel therapeutic effects to transplant recipients.
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