ArticleParasitology research2013
Synergistic effect of inhibitors of fatty acid desaturases on Trypanosoma parasites.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Phytochemistry, bioactivity, and medicinal use of Cannabis sativa roots: a comprehensive review.Journal of cannabis research · 2026Review
- Anti-ACS omega · 2025Article
- Lipid and fatty acid metabolism in trypanosomatids.Microbial cell (Graz, Austria) · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathway for unsaturated fatty acid biosynthesis is essential in trypanosomatid parasites and has been a key target in our work on the discovery and analysis of several inhibitory compounds. Here, we show the effect of novel inhibitors of stearoyl-CoA desaturase (SCD) and oleate desaturase (OD), alone and in combination, on the growth rate of parasite cultures. GS-456332, an inhibitor of human Δ9 desaturase, efficiently inhibited growth of both Trypanosoma cruzi epimastigotes and Trypanosoma brucei bloodstream form cells, with EC
Identifiers
23797276What OpenQuestion holds
Registered trials
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