ArticleDevelopmental and comparative immunology2013
Alternative splicing of the trout Pax5 gene and identification of novel B cell populations using Pax5 signatures.
Article in Developmental and comparative immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- The Pleiotropy ofInternational journal of molecular sciences · 2022Review
- Transient increase in abundance of B lineage but not myeloid-lineage cells in anterior kidney of sockeye salmon during return migration to the natal grounds.Fish & shellfish immunology · 2020Article
- Melanomacrophages and melanomacrophage centres inCentral-European journal of immunology · 2019Review
- Innate immune cell signatures in a BCWD-Resistant line of rainbow trout before and after in vivo challenge with Flavobacterium psychrophilum.Developmental and comparative immunology · 2019Article
- Long-Lived Plasma Cells Secrete High-Affinity Antibodies Responding to a T-Dependent Immunization in a Teleost Fish.Frontiers in immunology · 2019Article
- Specific humoral immunity inCentral-European journal of immunology · 2018Review
- A BCWD-resistant line of rainbow trout exhibits higher abundance of IgTDevelopmental and comparative immunology · 2017Article
- Expressed IgH μ and τ transcripts share diversity segment in ranched Thunnus orientalis.Developmental and comparative immunology · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pax5 is an alternatively spliced transcription factor that regulates B cell development and activation. The function of specific Pax5 isoforms is unknown. Here we report the existence of seven alternatively spliced isoforms of Pax5 in the rainbow trout. We hypothesized that B cells differentially express specific Pax5 isoforms as a means of modulating Pax5 activity during cell maturation. Flow cytometric analyses using Pax5-specific antibodies recognizing the paired domain, a central (exon 6-encoding) domain, or the C-terminus, revealed the existence of distinct Pax5-expressing cell populations in trout immune tissues. Additionally, using the transcription factor EBF, we show that Pax5 isoforms lacking a paired domain are already expressed at the earliest stages of trout (B) lymphopoiesis, and unexpectedly, that minor populations of such cells reside in blood and spleen. These data support use of differentially expressed Pax5 isoforms to identify novel B cell subsets in the form of Pax5 tissue signatures, and as such, provides new biomarkers for malignancy, infectious disease, and disease resistance in trout and humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.