Trial reportAmerican journal of respiratory and critical care medicine2013
Vasopressin compared with norepinephrine augments the decline of plasma cytokine levels in septic shock.
Trial report in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05506319 (Incidence of Hypotension in the Weaning From Vasopressor Drugs), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Incidence of Hypotension in the Weaning From Vasopressor Drugs
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Pooled it
- Vasopressors for hypotensive shock.The Cochrane database of systematic reviews · 2016Pooled it
- The Specific Organism: Not Bacterial Gram Type: Drives the Inflammatory Response in Septic Shock.Journal of innate immunity · 2020Trial
- Plasma cytokine levels predict response to corticosteroids in septic shock.Intensive care medicine · 2016Trial
- Trial
- Vasopressin and its analogues in patients with septic shock: holy Grail or unfulfilled promise?Critical care (London, England) · 2025Review
- The therapeutic effect of norepinephrine alone or in combination with vasopressin on septic shock patients: a meta-analysis.American journal of translational research · 2025Review
- Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis.Intensive care medicine · 2024Review
- Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024Review
- Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19.Journal of innate immunity · 2024Article
- Nomogram model for predicting secondary infection in critically ill patients with heatstroke: A pilot study from China.PloS one · 2024Article
- Review
- Article
- The order of vasopressor discontinuation and incidence of hypotension: a retrospective cohort analysis.Scientific reports · 2021Article
- Vasopressor therapy in critically ill patients with shock.Intensive care medicine · 2019Review
- The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders.Annals of the New York Academy of Sciences · 2019Review
- Combination era, using combined vasopressors showed benefits in treating septic shock patients: a network meta-analysis of randomized controlled trials.Annals of translational medicine · 2019Article
- Metabolic acidosis in critically ill patients with cirrhosis: Epidemiology and short-term mortality risk factors.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Model for end-stage liver disease and pneumonia: An improved scoring model for critically ill cirrhotic patients with pneumonia.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Shock - Classification and Pathophysiological Principles of Therapeutics.Current cardiology reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleChanges in plasma cytokine levels may predict mortality, and therapies (vasopressin versus norepinephrine) could change plasma cytokine levels in early septic shock.
objectivesOur hypotheses were that changes in plasma cytokine levels over 24 hours differ between survivors and nonsurvivors, and that there are different effects of vasopressin and norepinephrine on plasma cytokine levels in septic shock.
methodsWe studied 394 patients in a randomized, controlled trial of vasopressin versus norepinephrine in septic shock. We used hierarchical clustering and principal components analysis of the baseline cytokine concentrations to subgroup cytokines; we then compared survivors to nonsurvivors (28 d) and compared vasopressin- versus norepinephrine-induced changes in cytokine levels over 24 hours. MEASUREMENTS AND MAIN
resultsA total of 39 plasma cytokines were measured at baseline and at 24 hours. Hierarchical clustering and principal components analysis grouped cytokines similarly. Survivors (versus nonsurvivors) had greater decreases of overall cytokine levels (P < 0.001). Vasopressin decreased overall 24-hour cytokine concentration compared with norepinephrine (P = 0.037). In less severe septic shock, the difference in plasma cytokine reduction over 24 hours between survivors and nonsurvivors was less pronounced than that seen in more severe septic shock. Furthermore, vasopressin decreased interferon-inducible protein 10 and granulocyte colony-stimulating factor more than did norepinephrine in less severe septic shock, whereas vasopressin decreased granulocyte-macrophage colony-stimulating factor in patients who had more severe shock.
conclusionsSurvivors of septic shock had greater decreases of cytokines, chemokines and growth factors in early septic shock. Vasopressin decreased 24-hour plasma cytokine levels more than did norepinephrine. The vasopressin-associated decrease of cytokines differed according to severity of shock. Clinical trial registered with www.controlled-trials.com (ISRCTN94845869).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.