ArticleAging cell2013
Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs.
Article in Aging cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 66 citations in OpenAlex.
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- Phenotypical, Behavioral, and Systemic Hallmarks in End-Point Mouse Scenarios.Animals : an open access journal from MDPI · 2025Article
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- IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.Nature communications · 2023Article
- Protectin DX as a therapeutic strategy against frailty in mice.GeroScience · 2023Article
- Age-Related Changes in the Clustering of Blood Populations in Cynomolgus Monkeys Depend on Sex and Immune Status.Life (Basel, Switzerland) · 2023Article
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- Human Galectin-7 GeneFrontiers in molecular neuroscience · 2022Article
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- Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice.Mechanisms of ageing and development · 2021Article
- Tissue-specific Gene Expression Changes Are Associated with Aging in Mice.Genomics, proteomics & bioinformatics · 2020Article
- Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract.Developmental cell · 2020Article
- Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging.Genome research · 2019Article
- Article
- Betaine-homocysteineFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics.Kidney international · 2019Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Aging and age-related pathology is a result of a still incompletely understood intricate web of molecular and cellular processes. We present a C57BL/6J female mice in vivo aging study of five organs (liver, kidney, spleen, lung, and brain), in which we compare genome-wide gene expression profiles during chronological aging with pathological changes throughout the entire murine life span (13, 26, 52, 78, 104, and 130 weeks). Relating gene expression changes to chronological aging revealed many differentially expressed genes (DEGs), and altered gene sets (AGSs) were found in most organs, indicative of intraorgan generic aging processes. However, only ≤ 1% of these DEGs are found in all organs. For each organ, at least one of 18 tested pathological parameters showed a good age-predictive value, albeit with much inter- and intraindividual (organ) variation. Relating gene expression changes to pathology-related aging revealed correlated genes and gene sets, which made it possible to characterize the difference between biological and chronological aging. In liver, kidney, and brain, a limited number of overlapping pathology-related AGSs were found. Immune responses appeared to be common, yet the changes were specific in most organs. Furthermore, changes were observed in energy homeostasis, reactive oxygen species, cell cycle, cell motility, and DNA damage. Comparison of chronological and pathology-related AGSs revealed substantial overlap and interesting differences. For example, the presence of immune processes in liver pathology-related AGSs that were not detected in chronological aging. The many cellular processes that are only found employing aging-related pathology could provide important new insights into the progress of aging.
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