ReviewJournal of neuroendocrinology2013
The implication of neuroactive steroids in Tourette's syndrome pathogenesis: A role for 5α-reductase?
Review in Journal of neuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.Frontiers in neuroendocrinology · 2026Review
- Contemporary Perspectives on Neurobiology and Treatment of Tic Disorders: A Narrative Review.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026Article
- Clinical Profile and Plasma Vitamin B6 Levels in Children with Tourette Syndrome: A Case-control Study.Indian journal of psychological medicine · 2026Article
- Clinical Features, Mechanisms, and Management of Anxiety in Youth with Tic Disorders: A Narrative Review.Neuropsychiatric disease and treatment · 2026Review
- Epidemiology of Tourette Syndrome.Brain sciences · 2025Review
- The role of neuroactive steroids in tic disorders.Neuroscience and biobehavioral reviews · 2024Review
- Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?Journal of neuroendocrinology · 2022Review
- Neurobehavioural complications of sleep deprivation: Shedding light on the emerging role of neuroactive steroids.Journal of neuroendocrinology · 2020Review
- Isoallopregnanolone reduces tic-like behaviours in the D1CT-7 mouse model of Tourette syndrome.Journal of neuroendocrinology · 2020Article
- Repurposing steroidogenesis inhibitors for the therapy of neuropsychiatric disorders: Promises and caveats.Neuropharmacology · 2019Review
- The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats.Translational stroke research · 2019Article
- Tourette syndrome: a disorder of the social decision-making network.Brain : a journal of neurology · 2018Review
- Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models.Scientific reports · 2017Article
- The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating.Psychoneuroendocrinology · 2016Article
- Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?Reviews in endocrine & metabolic disorders · 2015Review
- Animal models of tic disorders: a translational perspective.Journal of neuroscience methods · 2014Review
- Bisphenol A modifies the regulation exerted by testosterone on 5 α -reductase isozymes in ventral prostate of adult rats.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Tourette's syndrome (TS) is a neurodevelopmental disorder characterised by recurring motor and phonic tics. The pathogenesis of TS is considered to reflect dysregulations in the signalling of dopamine (DA) and other neurotransmitters, which lead to excitation/inhibition imbalances in cortico-striato-thalamocortical circuits. The causes of these deficits may reflect complex gene × environment × sex (G × E × S) interactions; indeed, the disorder is markedly predominant in males, with a male-to-female prevalence ratio of approximately 4 : 1. Converging lines of evidence point to neuroactive steroids as being likely molecular candidates to account for G × E × S interactions in TS. Building on these premises, our group has begun examining the possibility that alterations in the steroid biosynthetic process may be directly implicated in TS pathophysiology; in particular, our research has focused on 5α-reductase (5αR), the enzyme catalysing the key rate-limiting step in the synthesis of pregnane and androstane neurosteroids. In clinical and preclinical studies, we found that 5αR inhibitors exerted marked anti-DAergic and tic-suppressing properties, suggesting a central role for this enzyme in TS pathogenesis. Based on these data, we hypothesise that enhancements in 5αR activity in early developmental stages may lead to an inappropriate activation of the 'backdoor' pathway for androgen synthesis from adrenarche until the end of puberty. We predict that the ensuing imbalances in steroid homeostasis may impair the signalling of DA and other neurotransmitters, ultimately resulting in the facilitation of tics and other behavioural abnormalities in TS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.