ArticleReproductive system & sexual disorders : current research2012
The Genetics of Keratoconus: A Review.
Article in Reproductive system & sexual disorders : current research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus.The Cochrane database of systematic reviews · 2014Pooled it
- Influence of interleukin 17 A and 17 F polymorphisms in keratoconus.Molecular biology reports · 2021Trial
- Proteomic Analysis Provides Insights Into PPIP5K2 Function and Its Impact on Corneal Energy Metabolism.Investigative ophthalmology & visual science · 2025Article
- Prevalence of Keratoconus and Associated Risk Factors Among High School Students in Couva, Trinidad: A Cross-Sectional Study.Vision (Basel, Switzerland) · 2025Article
- Genetics of Keratoconus: A Comprehensive Review.Genes · 2025Review
- Omics in Keratoconus: From Molecular to Clinical Practice.Journal of clinical medicine · 2025Review
- Targeted next-generation sequencing analysis in Italian patients with keratoconus.Eye (London, England) · 2024Article
- SMAD4-Dependent Signaling Pathway Involves in the Pathogenesis of TGFBR2-Related CE-like Phenotype.Cells · 2024Article
- Increased inflammatory mediators in the ocular surface tissue in keratoconus.Molecular vision · 2024Article
- Review
- Protective and pathogenic role of collagen subtypes genesSaudi journal of biological sciences · 2023Article
- Self-reported knowledge and skills related to diagnosis and management of keratoconus among public sector optometrists in the Limpopo province, South Africa.African journal of primary health care & family medicine · 2022Article
- Revealing the presence of tear extracellular vesicles in Keratoconus.Experimental eye research · 2022Article
- The Underlying Relationship between Keratoconus and Down Syndrome.International journal of molecular sciences · 2022Review
- [Corneal epithelial thickness in keratoconus patients compared to healthy controls].Die Ophthalmologie · 2022Article
- Dysregulation of Receptor for Advanced Glycation End Products (RAGE) Expression as a Biomarker of Keratoconus.Disease markers · 2022Article
- Novel Mutations Identified in the Chinese Han Population with Keratoconus by Next-Generation Sequencing.Journal of ophthalmology · 2022Article
- Corneal ectasia in mothers of Down syndrome children.Scientific reports · 2021Article
- Potential underlying genetic associations between keratoconus and diabetes mellitus.Advances in ophthalmology practice and research · 2021Article
- Tear proteomic profile in three distinct ocular surface diseases: keratoconus, pterygium, and dry eye related to graft-versus-host disease.Clinical proteomics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Keratoconus is the most common ectatic disorder of the corneal. Genetic and environmental factors may contribute to its pathogenesis. The focus of this article is to summarize current research into the complex genetics of keratoconus. We discuss the evidence of genetic etiology including family-based linkage studies, twin studies, genetic mutations, and genome-wide association studies. The genes implicated potentially include
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.