ArticleeLife2013
miR-124 controls male reproductive success in Drosophila.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Evolutionary basis of intermale sexual behavior by multiple pheromone switches inbioRxiv : the preprint server for biology · 2025Article
- The microRNA-29ab1/Zfp36/AR Axis in the Hypothalamus Regulates Male-Typical Behaviors in Mice.International journal of molecular sciences · 2024Article
- Article
- Regulation of insect behavior by non-coding RNAs.Science China. Life sciences · 2024Review
- Article
- An Insight Into the microRNA Profile of the Ectoparasitic MiteFrontiers in cellular and infection microbiology · 2022Article
- Evolution of Reproductive Behavior.Genetics · 2020Review
- PRAS40 hyperexpression promotes hepatocarcinogenesis.EBioMedicine · 2020Article
- Comparative analysis of microRNA expression profiles of adult Schistosoma japonicum isolated from water buffalo and yellow cattle.Parasites & vectors · 2019Article
- The Role of miRNAs inGenetics · 2019Article
- Advances in the Chemical Ecology of the Spotted Wing Drosophila (Drosophila suzukii) and its Applications.Journal of chemical ecology · 2018Review
- Characterization and comparative analysis of microRNAs in the rice pest Sogatella furcifera.PloS one · 2018Article
- Electrical synapses mediate synergism between pheromone and food odors inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Regulation of physiological processes by microRNAs in insects.Current opinion in insect science · 2015Article
- Loss of Drosophila pheromone reverses its role in sexual communication in Drosophila suzukii.Proceedings. Biological sciences · 2015Article
- Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.Developmental cell · 2014Article
- Wolbachia infection modifies the profile, shuttling and structure of microRNAs in a mosquito cell line.PloS one · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many aspects of social behavior are controlled by sex-specific pheromones. Gender-appropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of gender-appropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. DOI:http://dx.doi.org/10.7554/eLife.00640.001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.