Evidence map›Paper›PMID 23795230›Full record

ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2013

Folded Conformation, Cyclic Pentamer, Nano-Structure and PAD4 Binding Mode of YW3-56.

Haimei Zhu, Yuji Wang, Yaonan Wang, Shurui Zhao, Ming Zhao, Lin Gui, Wenyun Xu, Xiangyun Amy Chen, Yanming Wang, Shiqi Peng

Abstract read
In one paragraph

Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Citrullination in tumor immunity and therapy.The Journal of clinical investigation · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haimei ZhuCollege of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P.R. China.
Yuji Wang
Yaonan Wang
Shurui Zhao
Ming Zhao
Lin Gui
Wenyun Xu
Xiangyun Amy Chen
Yanming Wang
Shiqi Peng

Funding

Molecular mechanisms in the regulation of p53 functions by PAD4R01CA136856 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI WANG, YANMING · 2009 to 2013
$1.3M
NCI NIH HHS R01 CA136856
6 · The paper itself

Abstract

The physical and chemical mechanisms of small molecules with pharmacological activity forming nano-structures are developing into a new field of nano-medicine. By using ROESY 2D NMR spectroscopy, trandem mass spectroscopy, transmission electron microscopy and computer-assisted molecular modeling, this paper demonstrated the contribution of the folded conformation, the intra- and intermolecular π-π stacking, the intra- and intermolecular hydrogen bonds, and the receptor binding free energy of 6-dimethylaminonaph-2-yl-{N-S-[1-benzylcarba-moyl-4-(2-chloroacetamidobutyl)]-carboxamide (YW3-56) to the rapid formation of nano-rings and the slow formation of nano-capsules. Thus we have developed a strategy that makes it possible to elucidate the physical and chemical mechanisms of bioactive small molecules forming nano-structures.

Indexed as

Anti-cancerConformationMechanismNano-medicineNano-structurePAD4

Identifiers

PMID23795230
PMCPMC3685498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.