ArticleInternational journal of computers in healthcare2012
A cell-matrix model of anabolic and catabolic dynamics during cartilage biomolecule regulation.
Article in International journal of computers in healthcare, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment.Arthritis research & therapy · 2020Review
- Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice.Arthritis research & therapy · 2020Article
- Brain natriuretic peptide mitigates TIMP2 induction and reinstates extracellular matrix catabolic activityAmerican journal of translational research · 2019Article
- 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis.Journal of cellular and molecular medicine · 2018Article
- Computational model for the analysis of cartilage and cartilage tissue constructs.Journal of tissue engineering and regenerative medicine · 2016Article
- Ultrasonic wave propagation assessment of native cartilage explants and hydrogel scaffolds for tissue engineering.International journal of biomedical engineering and technology · 2012Article
- Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov's Theorem to Biomolecule Homeostasis.Journal of nanotechnology in engineering and medicine · 2011Article
- Three-Dimensional Culture of Cells and Matrix Biomolecules for Engineered Tissue Development and Biokinetics Model Validation.Journal of nanotechnology in engineering and medicine · 2011Article
- Volumetric stress-strain analysis of optohydrodynamically suspended biological cells.Journal of biomechanical engineering · 2011Article
- Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis.Journal of nanotechnology in engineering and medicine · 2010Article
- A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Static Nanomechanical Stimulation in a Cartilage Biokinetics Model.Journal of nanotechnology in engineering and medicine · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Physiologic regulation of extracellular matrix (ECM) in articular cartilage tissue is controlled by cellular and molecular mechanisms which are not fully understood. It has been observed that the synthesis of the ECM structural molecules, glycosaminoglycan and collagen are promoted by growth factors such as IGF-1 and TGF-β. Concomitant ECM degradation is promoted by a variety of cytokines such as IL-1. The clinical need for reparative therapies of articular cartilage is linked with its poor intrinsic healing capacity. The following modelling approach was applied to engineered cartilage as a platform for exploring cartilage biology and to introduce a predictive tool as a bioinformatic support system supporting regenerative therapies. Systems biology was adapted through a mathematical framework producing a computational intelligence paradigm to explore a controlled phasic regulatory influence of the inhibition and production of ECM biomolecules. Model outcomes describe a steady synthesis of ECM as a dependence on a cyclic influence of the catabolic action of proteases and anabolic action of growth factors. This relationship is shown quantitatively in a governing harmonic equation representing the simplified biological mechanisms of biomolecule homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.