Evidence map›Paper›PMID 23794736›Full record

ArticleDatabase : the journal of biological databases and curation2013

ESCAPE: database for integrating high-content published data collected from human and mouse embryonic stem cells.

Huilei Xu, Caroline Baroukh, Ruth Dannenfelser, Edward Y Chen, Christopher M Tan, Yan Kou, Yujin E Kim, Ihor R Lemischka, Avi Ma'ayan

Abstract read
In one paragraph

Article in Database : the journal of biological databases and curation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Computational Network Analysis for Defining Transcriptional Programs.Methods in molecular biology (Clifton, N.J.) · 2027
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huilei XuDepartment of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1215, New York, NY 10029, USA.
Caroline Baroukh
Ruth Dannenfelser
Edward Y Chen
Christopher M Tan
Yan Kou
Yujin E Kim
Ihor R Lemischka
Avi Ma'ayan

Funding

System Biology Center in New YorkP50GM071558 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZAPH, SUSANA NEVES · 2007 to 2017
$22.8M
Role of HIPK2 in Kidney Tubulointerstitial InjuryR01DK088541 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HE, JOHN CIJIANG · 2010 to 2019
$4.0M
Global & Systems Level Analyses of Cell Fate RegulationR01GM078465 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEMISCHKA, IHOR R · 2007 to 2015
$3.7M
Expression2Kinases: mRNA Profiling Linked to Multiple Upstream Regulatory LayersR01GM098316 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI · 2012 to 2015
$1.3M
Pursuing PluripotencyRC1GM091176 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEMISCHKA, IHOR R · 2010 to 2010
$1000k
NIDDK NIH HHS R01DK088541-01A1NIGMS NIH HHS P50 GM071558NIGMS NIH HHS P50GM071558-03NIGMS NIH HHS R01GM078465-03NIGMS NIH HHS R01 GM098316NIGMS NIH HHS R01GM098316-01A1NIGMS NIH HHS RC1GM091176-01
6 · The paper itself

Abstract

High content studies that profile mouse and human embryonic stem cells (m/hESCs) using various genome-wide technologies such as transcriptomics and proteomics are constantly being published. However, efforts to integrate such data to obtain a global view of the molecular circuitry in m/hESCs are lagging behind. Here, we present an m/hESC-centered database called Embryonic Stem Cell Atlas from Pluripotency Evidence integrating data from many recent diverse high-throughput studies including chromatin immunoprecipitation followed by deep sequencing, genome-wide inhibitory RNA screens, gene expression microarrays or RNA-seq after knockdown (KD) or overexpression of critical factors, immunoprecipitation followed by mass spectrometry proteomics and phosphoproteomics. The database provides web-based interactive search and visualization tools that can be used to build subnetworks and to identify known and novel regulatory interactions across various regulatory layers. The web-interface also includes tools to predict the effects of combinatorial KDs by additive effects controlled by sliders, or through simulation software implemented in MATLAB. Overall, the Embryonic Stem Cell Atlas from Pluripotency Evidence database is a comprehensive resource for the stem cell systems biology community. Database URL: http://www.maayanlab.net/ESCAPE

Indexed as

Databases as TopicPublicationsAnimalsBiomarkersCell LineageEmbryonic Stem CellsHigh-Throughput Screening AssaysHumansMicePluripotent Stem CellsSearch EngineBiomarkers

Identifiers

PMID23794736
PMCPMC3689438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.