ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Th17 cells induce Th1-polarizing monocyte-derived dendritic cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- IL17FMolecular medicine (Cambridge, Mass.) · 2026Article
- The trio of Candida albicans, immune cells, and cancer progression: a complex interplay driving tumorigenesis.Medical oncology (Northwood, London, England) · 2025Review
- Inhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival.Journal of inflammation research · 2021Article
- Human Regulatory Dendritic Cells Develop From Monocytes in Response to Signals From Regulatory and Helper T Cells.Frontiers in immunology · 2020Article
- IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Graft-versus-host Disease.Transplantation · 2019Article
- Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis.Immune network · 2019Review
- Th17 response in patients with cervical cancer.Oncology letters · 2018Review
- Mild hypothermia provides Treg stability.Scientific reports · 2017Article
- Th17 Cells in Protection from Tumor or Promotion of Tumor Progression.Journal of clinical & cellular immunology · 2016Article
- A Distinct Region in Erythropoietin that Induces Immuno/Inflammatory Modulation and Tissue Protection.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin.Immunologic research · 2014Article
- IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy.Hepatology (Baltimore, Md.) · 2014Article
- In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells.PloS one · 2013Article
- The plasticity of inflammatory monocyte responses to the inflamed central nervous system.Cellular immunologyReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
In chronically inflamed tissues, such as those affected by autoimmune disease, activated Th cells often colocalize with monocytes. We investigate in this study how murine Th cells influence the phenotype and function of monocytes. The data demonstrate that Th1, Th2, and Th17 subsets promote the differentiation of autologous monocytes into MHC class II(+), CD11b(+), CD11c(+) DC that we call DCTh. Although all Th subsets induce the formation of DCTh, activated Th17 cells uniquely promote the formation of IL-12/IL-23-producing DCTh (DCTh17) that can polarize both naive and Th17 cells to a Th1 phenotype. In the inflamed CNS of mice with Th17-mediated experimental autoimmune encephalomyelitis, Th cells colocalize with DC, as well as monocytes, and the Th cells obtained from these lesions drive the formation of DCTh that are phenotypically indistinguishable from DCTh17 and polarize naive T cells toward a Th1 phenotype. These results suggest that DCTh17 are critical in the interplay of Th17- and Th1-mediated responses and may explain the previous finding that IL-17-secreting Th cells become IFN-γ-secreting Th1 cells in experimental autoimmune encephalomyelitis and other autoimmune disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.