ArticleJournal of bacteriology2013
Evolutionary dynamics of the prokaryotic adaptive immunity system CRISPR-Cas in an explicit ecological context.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- CRISPR-Cas spacer acquisition is a rare event in human gut microbiome.Cell genomics · 2025Article
- Ecological drivers of CRISPR immune systems.mSystems · 2024Article
- Distribution of specific prokaryotic immune systems correlates with host optimal growth temperature.NAR genomics and bioinformatics · 2024Article
- Punctuated virus-driven succession generates dynamical alternations in CRISPR-mediated microbe-virus coevolution.Journal of the Royal Society, Interface · 2024Article
- Dynamics of CRISPR-mediated virus-host interactions in the human gut microbiome.The ISME journal · 2024Article
- Transient eco-evolutionary dynamics early in a phage epidemic have strong and lasting impact on the long-term evolution of bacterial defences.PLoS biology · 2023Article
- Controlling the human microbiome.Cell systems · 2023Review
- Article
- A precise review on NAATs-based diagnostic assays for COVID-19: A motion in fast POC molecular tests.European journal of clinical investigation · 2022Review
- Characterization of Marinilongibacter aquaticus gen. nov., sp. nov., a unique marine bacterium harboring four CRISPR-Cas systems in the phylum Bacteroidota.Journal of microbiology (Seoul, Korea) · 2022Article
- Epidemiological and evolutionary consequences of different types of CRISPR-Cas systems.PLoS computational biology · 2022Article
- Single cell variability of CRISPR-Cas interference and adaptation.Molecular systems biology · 2022Article
- High viral abundance and low diversity are associated with increased CRISPR-Cas prevalence across microbial ecosystems.Current biology : CB · 2022Article
- Global phylogenomic novelty of the Cas1 gene from hot spring microbial communities.Frontiers in microbiology · 2022Article
- Precipitous Increase of Bacterial CRISPR-Cas Abundance at Around 45°C.Frontiers in microbiology · 2022Article
- Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks.Proceedings. Biological sciences · 2021Article
- Long-run bacteria-phage coexistence dynamics under natural habitat conditions in an environmental biotechnology system.The ISME journal · 2021Article
- The network structure and eco-evolutionary dynamics of CRISPR-induced immune diversification.Nature ecology & evolution · 2020Article
- It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- New virus isolates from Italian hydrothermal environments underscore the biogeographic pattern in archaeal virus communities.The ISME journal · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
A stochastic, agent-based mathematical model of the coevolution of the archaeal and bacterial adaptive immunity system, CRISPR-Cas, and lytic viruses shows that CRISPR-Cas immunity can stabilize the virus-host coexistence rather than leading to the extinction of the virus. In the model, CRISPR-Cas immunity does not specifically promote viral diversity, presumably because the selection pressure on each single proto-spacer is too weak. However, the overall virus diversity in the presence of CRISPR-Cas grows due to the increase of the host and, accordingly, the virus population size. Above a threshold value of total viral diversity, which is proportional to the viral mutation rate and population size, the CRISPR-Cas system becomes ineffective and is lost due to the associated fitness cost. Our previous modeling study has suggested that the ubiquity of CRISPR-Cas in hyperthermophiles, which contrasts its comparative low prevalence in mesophiles, is due to lower rates of mutation fixation in thermal habitats. The present findings offer a complementary, simpler perspective on this contrast through the larger population sizes of mesophiles compared to hyperthermophiles, because of which CRISPR-Cas can become ineffective in mesophiles. The efficacy of CRISPR-Cas sharply increases with the number of proto-spacers per viral genome, potentially explaining the low information content of the proto-spacer-associated motif (PAM) that is required for spacer acquisition by CRISPR-Cas because a higher specificity would restrict the number of spacers available to CRISPR-Cas, thus hampering immunity. The very existence of the PAM might reflect the tradeoff between the requirement of diverse spacers for efficient immunity and avoidance of autoimmunity.
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