ArticleObesity (Silver Spring, Md.)2014
Gene-by-age effects on BMI from birth to adulthood: the Fels Longitudinal Study.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A genome-wide association study of body mass index across early life and childhood.International journal of epidemiology · 2015Pooled it
- Associations of taste receptor gene variants with Body Mass Index (BMI) and longevity.Scientific reports · 2026Article
- Longitudinal prediction of BMI using explainable AI: integrating polygenic scores, maternal, early-life and familial factors.International journal of obesity (2005) · 2026Observational
- Genetic contributions to body mass index over adolescence and its associations with adult weight gain: a 25-year follow-up study of Finnish twins.International journal of obesity (2005) · 2025Article
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- Risk factors affecting polygenic score performance across diverse cohorts.medRxiv : the preprint server for health sciences · 2024Article
- Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2023Article
- Identification of five genetic variants with differential effects on obesity-related traits based on age.Frontiers in genetics · 2022Article
- Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty.Journal of clinical medicine · 2020Article
- Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study.BMC medical genetics · 2018Article
- Article
- Body mass index associations between mother and offspring from birth to age 18: the Fels Longitudinal Study.Obesity science & practice · 2017Article
- GW-SEM: A Statistical Package to Conduct Genome-Wide Structural Equation Modeling.Behavior genetics · 2017Article
- Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility.American journal of epidemiology · 2017Article
- Progressive influence of body mass index-associated genetic markers in rural Gambians.Journal of medical genetics · 2015Article
- Dopamine D4 receptor polymorphism and sex interact to predict children's affective knowledge.Frontiers in psychology · 2015Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectivesGenome wide association studies have shown 32 loci to influence BMI in European-American adults but replication in other studies is inconsistent and may be attributed to gene-by-age effects. The aims of this study were to determine if the influence of the summed risk score of these 32 loci (GRS) on BMI differed across age from birth to 40 years, and to determine if additive genetic effects other than those in the GRS differed by age.
methodsSerial measures of BMI were calculated at 0, 1, 3, 6, 9, 12, 18, and 28 months, and 4, 7, 11, 15, 19, 23, 30, and 40 years for 1,176 (605 females, 571 males) European-American participants in the Fels Longitudinal Study. SOLAR was used for genetic analyses.
resultsGRS was significant (P < 0.05) at ages: 6, 9 months, 4-15 years, and 23-40 years. Remaining additive genetic effects independently influenced BMI (P < 5.3 × 10(-5) , 0.40 < h(2) < 0.76). Some genetic correlations between ages were not significant. Differential GRS effects did not retain significance after multiple comparisons adjustments.
conclusionsWhile well-known BMI variants do not appear to have significant differential effects, other additive genes differ over the lifespan.
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