SynthesisJournal of molecular neuroscience : MN2013
Genome-wide pathway analysis in major depressive disorder.
Synthesis in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Genetic Contributions of Inflammation to Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Pooled it
- Psychological stress during medical internship is associated with inflammatory signatures linked to mental health.Brain, behavior, & immunity - health · 2026Article
- Progress and challenges in exploring the pathogenesis of depressive disorders via RNA sequencing.Frontiers in genetics · 2026Review
- A Transcriptomic Signature of Depressive Symptoms in Late Life.Biological psychiatry global open science · 2025Article
- Article
- iHerd: an integrative hierarchical graph representation learning framework to quantify network changes and prioritize risk genes in disease.PLoS computational biology · 2023Article
- Computed tomography-detected extramural venous invasion-related gene signature: a potential negative biomarker of immune checkpoint inhibitor treatment in patients with gastric cancer.Journal of translational medicine · 2023Article
- The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas.International journal of molecular sciences · 2022Article
- Integration of Transcriptome and Exome Genotyping Identifies Significant Variants with Autism Spectrum Disorder.Pharmaceuticals (Basel, Switzerland) · 2022Article
- CT-detected extramural venous invasion-related gene signature for the overall survival prediction in patients with gastric cancer.Cancer medicine · 2021Article
- Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape.Translational psychiatry · 2021Article
- Development and Clinical Validation of a Novel 4-Gene Prognostic Signature Predicting Survival in Colorectal Cancer.Frontiers in oncology · 2020Article
- CFrontiers in neurology · 2020Review
- DNA methylation signatures of educational attainment.NPJ science of learning · 2018Article
- Genetics Factors in Major Depression Disease.Frontiers in psychiatry · 2018Review
- Systems Genomics Support for Immune and Inflammation Hypothesis of Depression.Current neuropharmacology · 2016Review
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- The role of ventral striatal cAMP signaling in stress-induced behaviors.Nature neuroscience · 2015Article
- Coordinated messenger RNA/microRNA changes in fibroblasts of patients with major depression.Biological psychiatry · 2015Article
- [Predictive factors of depression and its therapy].Der Nervenarzt · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of this study were: (1) to identify candidate single-nucleotide polymorphisms (SNPs) and mechanisms of major depressive disorder (MDD) and (2) to generate SNP-to-gene-to-pathway hypotheses. An MDD genome-wide association study (GWAS) data set that included 365,419 SNPs in 1,821 MDD cases and 1,822 controls of European descent was used in this study. Identify Candidate Causal SNPs and Pathway (ICSNPathway) analysis was applied to the GWAS dataset. ICSNPathway analysis identified 21 candidate SNPs, 16 genes, and 5 pathways, which provided 16 hypothetical biological mechanisms. The strongest hypothetical biological mechanism was that rs3213764 alters the role of ATF7IP in the context of the pathways of negative regulation of transcription, negative regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic processes and negative regulation of gene expression (nominal p < 0.001, FDR = 0.043, 0.044, and 0.046, respectively). Five of 16 candidate genes are known to be associated with inflammatory or immune response that may be associated with MDD: ANPEP, PRDM1, ZBTB32, MMP8, and ENPEP. By applying the ICSNPathway analysis to the MDD GWAS data, 21 candidate SNPs, 16 genes that included ATF7IP, ANPEP, PRDM1, ZBTB32, MMP8, and ENPEP, and 5 pathways that involved negative regulation of transcription and nucleic acid metabolism were identified that may contribute to MDD susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.