Trial reportCancer2013
Near-infrared fluorescence-guided resection of colorectal liver metastases.
Trial report in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Indocyanine green fluorescence navigation in robotic liver segmentectomies: a systematic review and meta-analysis.Journal of robotic surgery · 2025Pooled it
- European Association for Endoscopic Surgery (EAES) consensus on Indocyanine Green (ICG) fluorescence-guided surgery.Surgical endoscopy · 2023Pooled it
- Intraoperative fluorescence imaging with indocyanine green in hepatic resection for malignancy: a systematic review and meta-analysis of diagnostic test accuracy studies.Surgical endoscopy · 2020Pooled it
- [Indocyanine green fluorescence staining in liver surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Pooled it
- Current and future intraoperative imaging strategies to increase radical resection rates in pancreatic cancer surgery.BioMed research international · 2014Pooled it
- Efficacy and safety of indocyanine green-fluorescence imaging guided liver resection: a single-arm prospective cohort study.Langenbeck's archives of surgery · 2025Trial
- ICG-Fluorescence Imaging for Margin Assessment During Minimally Invasive Colorectal Liver Metastasis Resection.JAMA network open · 2024Trial
- A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial.Surgical endoscopy · 2020Trial
- Real-time surveillance of surgical margins via ICG-based near-infrared fluorescence imaging in patients with OSCC.World journal of surgical oncology · 2020Trial
- Prospective trial with optical molecular imaging for percutaneous interventions in focal hepatic lesions.Radiology · 2015Trial
- First experience on laparoscopic near-infrared fluorescence imaging of hepatic uveal melanoma metastases using indocyanine green.Surgical innovation · 2015Trial
- Trial
- Preoperative chemotherapy reduces the accumulation of indocyanine green around colorectal liver metastases for use in fluorescence-guided surgery.Surgical endoscopy · 2025Article
- Article
- Integration of near-infrared fluorescence imaging and Sonazoid contrast-enhanced ultrasound in laparoscopic resection of colorectal liver metastases: a dual-center retrospective study.Surgical endoscopy · 2025Article
- Review
- Applications of Indocyanine Green in Breast Cancer for Sentinel Lymph Node Mapping: Protocol for a Scoping Review.JMIRx med · 2025Article
- Review of Clinically Assessed Molecular Fluorophores for Intraoperative Image Guided Surgery.Molecules (Basel, Switzerland) · 2024Review
- Erythrocyte nano-ghosts with dual optical and magnetic resonance characteristics.Journal of biomedical optics · 2024Article
- Mechanisms of delayed indocyanine green fluorescence and applications to clinical disease processes.Surgery · 2024Review
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThe fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find during surgery using conventional techniques. The objectives of this study were to determine if optical imaging, using a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, to optimize dose and timing, and to determine the mechanism of contrast agent accumulation.
methodsThe high tissue penetration of near-infrared (NIR) light was exploited by use of the FLARE (Fluorescence-Assisted Resection and Exploration) image-guided surgery system and the NIR fluorophore indocyanine green in a clinical trial of 40 patients undergoing hepatic resection for colorectal cancer metastases.
resultsA total of 71 superficially located (< 6.2 mm beneath the liver capsule) colorectal liver metastases were identified and resected using NIR fluorescence imaging. Median tumor-to-liver ratio was 7.0 (range, 1.9-18.7) and no significant differences between time points or doses were found. Indocyanine green fluorescence was seen as a rim around the tumor, which is shown to be entrapment around cytokeratin 7-positive hepatocytes compressed by the tumor. Importantly, in 5 of 40 patients (12.5%, 95% confidence interval = 5.0-26.6), additional small and superficially located lesions were detected using NIR fluorescence, and were otherwise undetectable by preoperative computed tomography, intraoperative ultrasound, visual inspection, and palpation.
conclusionsNIR fluorescence imaging, even when used with a nontargeted, clinically available NIR fluorophore, is complementary to conventional imaging and able to identify missed lesions by other modalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.