ArticleJournal of molecular histology2013
Localization of Beclin1 in mouse developing tooth germs: possible implication of the interrelation between autophagy and apoptosis.
Article in Journal of molecular histology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of gestational protein restriction on autophagy dynamics during odontogenesis.Cell and tissue research · 2026Article
- The role of autophagy in odontogenesis, dental implant surgery, periapical and periodontal diseases.Journal of cellular and molecular medicine · 2024Review
- Dynamic patterns of histone lactylation during early tooth development in mice.Journal of molecular histology · 2023Article
- Orthodontic loading activates cell-specific autophagy in a force-dependent manner.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2022Article
- Roles of autophagy in orthodontic tooth movement.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2021Article
- Epigenetic Control of Autophagy Related Genes Transcription in Pulpitis via JMJD3.Frontiers in cell and developmental biology · 2021Article
- Role of Cell Death in Cellular Processes During Odontogenesis.Frontiers in cell and developmental biology · 2021Review
- Induction of autophagy protects human dental pulp cells from lipopolysaccharide-induced pyroptotic cell death.Experimental and therapeutic medicine · 2020Article
- Autophagy and its implication in human oral diseases.Autophagy · 2017Review
- Expression patterns of WNT/β-CATENIN signaling molecules during human tooth development.Journal of molecular histology · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous study identified the appearance of autophagy in developing tooth germs, and suggested its possible association with apoptosis in odontogenesis. Beclin1 was recently indicated to play a central role in bridging autophagy and apoptosis, and occupied a key position in the process of development. This study hypothesized that Beclin1 may be involved, and act as the molecular basis of the connection between autophagy and apoptosis in odontogenesis. Immunohistochemical analysis showed the spatiotemporal expression pattern of Beclin1 in odontogenesis from embryonic (E) day 13.5 to postnatal (P) day 5.5. At E stages, Beclin1 was mainly immunolocalized in the cytoplasm of the cells in the enamel organ. Meanwhile, the nucleus localization of Beclin1 was detected in part of the stellate reticulum, outer and inner enamel epithelium, especially at E16.5 and E18.5. At P stages, Beclin1 was detected in the cytoplasm of the odontoblasts, besides the dental epithelium cells. Triple immunofluorescence analysis showed the partial colocalization of Beclin1, autophagic marker LC3, or activated caspase-3 in the E14.5 tooth germs, especially the Beclin1(+)LC3(+)Caspase-3(+) cells in the PEK. Furthermore, western blot analysis revealed that the full-length (60 kDa) and/or cleaved (50, 37, and 35 kDa) Beclin1 in the developing tooth germs. Taken together, our findings indicate that Beclin1 is involved, and might be responsible for the crosstalk between autophagy and apoptosis in mouse odontogenesis.
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