Observational studyIntensive care medicine2013
Autonomic dysfunction in ICU-acquired weakness: a prospective observational pilot study.
Observational study in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Heart rate variability biofeedback for critical illness polyneuropathy: a randomized sham-controlled study.European journal of neurology · 2024Trial
- Medication Effects on Heart Rate Variability in Critical Illness: The Overlooked Confounder.Critical care explorations · 2026Review
- Ultrafiltration in the critically ill patient: a framework for personalized care.Critical care (London, England) · 2026Review
- Heart Rate Variability During Weaning from Invasive Mechanical Ventilation: A Systematic Review.Journal of clinical medicine · 2024Review
- Cardiopulmonary coupling indices to assess weaning readiness from mechanical ventilation.Scientific reports · 2021Article
- Heart rate variability in critical care medicine: a systematic review.Intensive care medicine experimental · 2017Article
- [Critical illness myopathy and polyneuropathy].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- Stress Reactivity in Chronic Tinnitus.Scientific reports · 2017Article
- [Critical illness polyneuropathy and myopathy as neurological complications of sepsis].Der Nervenarzt · 2016Review
- Clinical review: intensive care unit acquired weakness.Critical care (London, England) · 2015Review
- Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study.Critical care (London, England) · 2015Observational
- Steroids for acute respiratory distress syndrome?Clinics in chest medicine · 2014Review
- Year in review in Intensive Care Medicine 2013: I. Acute kidney injury, ultrasound, hemodynamics, cardiac arrest, transfusion, neurocritical care, and nutrition.Intensive care medicine · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntensive care unit-acquired weakness (ICU-AW) is a frequent complication of critical illness. It is unknown if patients with ICU-AW also have autonomic dysfunction, another frequent neurological complication of critical illness. We hypothesized that patients who develop ICU-AW also develop autonomic dysfunction. Furthermore, we hypothesized that patients with ICU-AW are more prone to develop autonomic dysfunction compared to patients without ICU-AW.
methodsThis was an observational cohort study of patients newly admitted to the ICU. Autonomic dysfunction was measured daily using heart rate variability (HRV) to a maximum of 15 days after admission. ICU-AW was diagnosed using the Medical Research Council score. Abnormal HRV was defined using age-matched reference values. The association between ICU-AW and HRV was analyzed using linear mixed effects models.
resultsWe included 83 patients, 15 (18 %) of whom were diagnosed with ICU-AW. Of 279 HRV measurements, 204 could be analyzed. Abnormal HRV was found in all critically ill patients irrespective of the presence of ICU-AW (ICU-AW 100 % (IQR 71-100) vs. no ICU-AW 100 % (IQR 40-100); p = 0.40). Mechanical ventilation, sedation, norepinephrine, heart rate, and HRV artifacts were identified as confounders for HRV. ICU-AW was not associated with HRV.
conclusionAbnormal HRV is frequent in critically ill patients, both with and without ICU-AW. It is unlikely that patients with ICU-AW are more prone to develop abnormal HRV. However, we found that abnormal HRV may not be an accurate indicator of autonomic dysfunction because of confounders.
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