Observational studyNeuroradiology2013
Relationship between thrombus attenuation and different stroke subtypes.
Observational study in Neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke.Neuroradiology · 2016Trial
- Effect of X-Ray Attenuation of Arterial Obstructions on Intravenous Thrombolysis and Outcome after Ischemic Stroke.PloS one · 2015Trial
- Widened arterial time-density curves of CTP may identify cardioembolic etiology in acute large-artery occlusion stroke.Neuroradiology · 2026Article
- Clinical image analysis to build patient-specific models of acute ischemic stroke patients.Physical and engineering sciences in medicine · 2026Article
- Multimaterial decomposition in dual-energy CT for characterization of clots from acute ischemic stroke patients.European radiology experimental · 2024Article
- Thrombus imaging characteristics within acute ischemic stroke: similarities and interdependence.Journal of neurointerventional surgery · 2023Article
- Heterogeneity between proximal and distal aspects of occlusive thrombi on pretreatment imaging in acute ischemic stroke.The neuroradiology journal · 2022Article
- Development and reliability of the histological THROMBEX-classification rule for thrombotic emboli of acute ischemic stroke patients.Neurological research and practice · 2021Article
- First approach to distinguish between cardiac and arteriosclerotic emboli of individual stroke patients applying the histological THROMBEX-classification rule.Scientific reports · 2021Article
- Implications of the Presence of Hyperdense Middle Cerebral Artery Sign in Determining the Subtypes of Stroke Etiology.Stroke research and treatment · 2021Article
- Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots.PloS one · 2019Article
- Erythrocyte-Rich Thrombus Is Associated with Reduced Number of Maneuvers and Procedure Time in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy.Cerebrovascular diseases extra · 2018Article
- Impact of hyperlipidemia and atrial fibrillation on the efficacy of endovascular treatment for acute ischemic stroke: a meta-analysis.Oncotarget · 2017Article
- Intracranial Thrombus Morphology and Composition Undergoes Time-Dependent Changes in Acute Ischemic Stroke: A CT Densitometry Study.International journal of molecular sciences · 2016Article
- Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke.International journal of molecular sciences · 2016Article
- Immunohistochemical Analysis of Cerebral Thrombi Retrieved by Mechanical Thrombectomy from Patients with Acute Ischemic Stroke.International journal of molecular sciences · 2016Article
- Article
- Histopathologic composition of cerebral thrombi of acute stroke patients is correlated with stroke subtype and thrombus attenuation.PloS one · 2014Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMore insights in the etiopathogenesis of thrombi could be helpful in the treatment of patients with acute ischemic stroke. The aim of our study was to determine the relationship between presence of a hyperdense vessel sign and thrombus density with different stroke subtypes.
methodsWe included 123 patients with acute ischemic anterior circulation stroke and a visible occlusion on CT-angiography caused by cardioembolism (n = 53), large artery atherosclerosis (n = 55), or dissection (n = 15). Presence or absence of a hyperdense vessel sign was assessed and thrombus density was measured in Hounsfield Units (HU) on non-contrast 1 mm thin slices CT. Subsequently, occurrence of hyperdense vessel sign and thrombus density (absolute HU and rHU (=HU thrombus/HU contralateral)) were related with stroke subtypes.
resultsThe presence of hyperdense vessel signs differed significantly among subtypes and was found in 45, 64 and 93 % of patients with cardioembolism, large artery atherosclerosis and dissection, respectively (p = 0.003). The mean HU and rHU (+95 % CI) of the thrombi in all vessels were respectively 56.1 (53.2-59.0) and 1.39 (1.33-1.45) in cardioembolism, 64.6 (62.2-66.9) and 1.59 (1.54-1.64) in large artery atherosclerosis and 76.4 (73.0-79.8) and 1.88 (1.79-1.97) in dissection (p < 0.0001). We found the same significant ranking order in the density of thrombi with hyperdense vessel signs (mean HU and rHU (+95 % CI), respectively): cardioembolism 61.3 (57.4-65.3) and 1.49 (57.4-65.3); large artery atherosclerosis 67.3 (64.9-69.7) and 1.65 (1.58-1.71); dissection 76.4 (72.6-80.1) and 1.89 (1.79-1.99, p < 0.0001).
conclusionPresence of a hyperdense vessel sign and thrombus density are related to stroke subtype.
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