ArticleThe Journal of membrane biology2013
Extracting curvature preferences of lipids assembled in flat bilayers shows possible kinetic windows for genesis of bilayer asymmetry and domain formation in biological membranes.
Article in The Journal of membrane biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling.The Journal of membrane biology · 2022Article
- Osmotic tolerance of avian erythrocytes to complete hemolysis in solute free water.Scientific reports · 2019Article
- Occurrence of tocopheryl fatty acid esters in vegetables and their non-digestibility by artificial digestion juices.Scientific reports · 2018Article
- Transmembrane Domain Lengths Serve as Signatures of Organismal Complexity and Viral Transport Mechanisms.Scientific reports · 2016Article
- A statistical anomaly indicates symbiotic origins of eukaryotic membranes.Molecular biology of the cell · 2015Article
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2 authors.
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Abstract
Studies on the assembly of pure lipid components allow mechanistic insights toward understanding the structural and functional aspects of biological membranes. Molecular dynamic (MD) simulations on membrane systems provide molecular details on membrane dynamics that are difficult to obtain experimentally. A large number of MD studies have remained somewhat disconnected from a key concept of amphipathic assembly resulting in membrane structures--shape parameters of lipid molecules in those structures in aqueous environments. This is because most of the MD studies have been done on flat lipid membranes. With the above in view, we analyzed MD simulations of 26 pure lipid patches as a function of (1) lipid type(s) and (2) time of MD simulations along with 35-40 ns trajectories of five pure lipids. We report, for the first time, extraction of curvature preferences of lipids from MD simulations done on flat bilayers. Our results may lead to mechanistic insights into the possible origins of bilayer asymmetries and domain formation in biological membranes.
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