Evidence map›Paper›PMID 23793750›Full record

ArticleBioinformatics (Oxford, England)2013

cisExpress: motif detection in DNA sequences.

Martin Triska, David Grocutt, James Southern, Denis J Murphy, Tatiana Tatarinova

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Martin TriskaGenomics and Computational Biology Research Group, Faculty of Computing, Engineering and Science, University of South Wales, Pontypridd, UK.
David Grocutt
James Southern
Denis J Murphy
Tatiana Tatarinova

Funding

Populaton Pharmacokinetic Modeling and Optimal ControlR01GM068968 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NEELY, MICHAEL N. · 2003 to 2015
$3.9M
Mechanisms of Hypothermic Neuroprotection in NeonatesR01HD070996 · NICHD · JOHNS HOPKINS UNIVERSITY · PI NORTHINGTON, FRANCES J · 2012 to 2016
$1.7M
NICHD NIH HHS HD070996NICHD NIH HHS R01 HD070996NIGMS NIH HHS GM068968NIGMS NIH HHS R01 GM068968
6 · The paper itself

Abstract

motivationOne of the major challenges for contemporary bioinformatics is the analysis and accurate annotation of genomic datasets to enable extraction of useful information about the functional role of DNA sequences. This article describes a novel genome-wide statistical approach to the detection of specific DNA sequence motifs based on similarities between the promoters of similarly expressed genes. This new tool, cisExpress, is especially designed for use with large datasets, such as those generated by publicly accessible whole genome and transcriptome projects. cisExpress uses a task farming algorithm to exploit all available computational cores within a shared memory node. We demonstrate the robust nature and validity of the proposed method. It is applicable for use with a wide range of genomic databases for any species of interest. AVAILABILITY: cisExpress is available at www.cisexpress.org.

Indexed as

Promoter Regions, GeneticSoftwareAlgorithmsArabidopsisDNAGenomicsNucleotide MotifsSequence Analysis, DNADNA

Identifiers

PMID23793750
PMCPMC3740630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.