ArticleFunctional & integrative genomics2013
Identifying genetic diversity of avirulence genes in Leptosphaeria maculans using whole genome sequencing.
Article in Functional & integrative genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Genomic footprints related with adaptation and fumonisins production inFrontiers in microbiology · 2022Article
- Landscape of genomic diversity and host adaptation in Fusarium graminearum.BMC genomics · 2017Article
- Current Status and Challenges in Identifying Disease Resistance Genes inFrontiers in plant science · 2017Review
- Genome-wide Association Study Identifies New Loci for Resistance toFrontiers in plant science · 2016Article
- Gene loss in the fungal canola pathogen Leptosphaeria maculans.Functional & integrative genomics · 2015Article
- Scanning the effects of ethyl methanesulfonate on the whole genome of Lotus japonicus using second-generation sequencing analysis.G3 (Bethesda, Md.) · 2015Article
- Patterns of genomic variation in the poplar rust fungus Melampsora larici-populina identify pathogenesis-related factors.Frontiers in plant science · 2014Article
- Next-generation genome sequencing can be used to rapidly characterise sequences flanking T-DNA insertions in random insertional mutants ofFungal biology and biotechnology · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Next generation sequencing technology allows rapid re-sequencing of individuals, as well as the discovery of single nucleotide polymorphisms (SNPs), for genomic diversity and evolutionary analyses. By sequencing two isolates of the fungal plant pathogen Leptosphaeria maculans, the causal agent of blackleg disease in Brassica crops, we have generated a resource of over 76 million sequence reads aligned to the reference genome. We identified over 21,000 SNPs with an overall SNP frequency of one SNP every 2,065 bp. Sequence validation of a selection of these SNPs in additional isolates collected throughout Australia indicates a high degree of polymorphism in the Australian population. In preliminary phylogenetic analysis, isolates from Western Australia clustered together and those collected from Brassica juncea stubble were identical. These SNPs provide a novel marker resource to study the genetic diversity of this pathogen. We demonstrate that re-sequencing provides a method of validating previously characterised SNPs and analysing differences in important genes, such as the disease related avirulence genes of L. maculans. Understanding the genetic characteristics of this devastating pathogen is vital in developing long-term solutions to managing blackleg disease in Brassica crops.
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Registered trials
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