Evidence map›Paper›PMID 23793554›Full record

ArticleMolecular and cellular biochemistry2013

Resveratrol repressed viability of U251 cells by miR-21 inhibiting of NF-κB pathway.

Hongxiu Li, Zhijun Jia, Aimei Li, Gareth Jenkins, Xin Yang, Jun Hu, Wanhua Guo

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Human miRNAs in Cancer: Statistical Trends and Cross Kingdom Approach.International journal of molecular sciences · 2025
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  15. Molecular Targets of Natural Compounds with Anti-Cancer Properties.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hongxiu LiDepartment of Oncology, Ningbo Mingzhou Hospital, 188 Taian Xi Road, Ningbo, 315899, China.
Zhijun Jia
Aimei Li
Gareth Jenkins
Xin Yang
Jun Hu
Wanhua Guo
Nanjing Drum Tower Hospital · CNNanjing University of Posts and Telecommunications · CNNingbo No. 2 Hospital · CNUniversity of Nottingham Ningbo China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol (RSV), a polyphenol, is known to play an important role in inhibiting proliferation and inducing apoptosis of glioma cells. The aim of this study was to explore the mechanism of RSV on U251 cells apoptosis. RSV showed a dose-dependent decrease in U251 cell viability. It could reduce IκB phosphorylation, nuclear P65 protein levels and NF-κB transcriptional activity, which suggested that signaling pathway are involved in RSV-induced apoptosis. In addition, RSV could inhibit miR-21 expression and down-regulation of miR-21 expression could suppress NF-κB activity. Interestingly, over-expression of miR-21 can reverse the effect of RSV on NF-κB activity and apoptosis in U251 cells. These results suggest that RSV can effectively induce apoptosis of U251 cells and modulation of miR-21 possibly contributes to this antitumor action.

Indexed as

ApoptosisCell Line, TumorCell SurvivalDown-RegulationGene Expression Regulation, NeoplasticHumansMicroRNAsNF-kappa BResveratrolSignal TransductionStilbenesMicroRNAsMIRN21 microRNA, humanNF-kappa BResveratrolStilbenes

Identifiers

PMID23793554
OpenAlexW1996602595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.