ArticleParasitology research2013
Antimalarial activity of Bergenia ciliata (Haw.) Sternb. against Plasmodium berghei.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Pharmacological properties of Bergenia ciliata synthesized green zinc sulfide nanoparticles (ZnS-NPs) and zinc oxide nanoparticles (ZnO-NPs).Bioprocess and biosystems engineering · 2025Article
- Phytochemical Analysis and Antioxidant and Antidiabetic Activities of Extracts fromAdvances in pharmacological and pharmaceutical sciences · 2022Article
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Review
- β-Carboline Derivatives Tackling Malaria: Biological Evaluation and Docking Analysis.ACS omega · 2020Article
- Synthesis and Evaluation of Antiplasmodial Efficacy of β-Carboline Derivatives against Murine Malaria.ACS omega · 2018Article
- Factors Contributing to the Decline of Traditional Practices in Communities from the Gwallek-Kedar area, Kailash Sacred Landscape, Nepal.Environmental management · 2018Article
- Evaluation ofJournal of traditional and complementary medicine · 2018Article
- Antioxidant, antimicrobial activity and bioactive compounds ofJournal of traditional and complementary medicine · 2017Article
- Antiplasmodial activity of eco-friendly synthesized palladium nanoparticles using Eclipta prostrata extract against Plasmodium berghei in Swiss albino mice.Parasitology research · 2015Article
- In vitro biological evaluation of 100 selected methanol extracts from the traditional medicinal plants of Asia.Nutrition research and practice · 2014Article
- In vivo antimalarial evaluation of MAMA decoction on Plasmodium berghei in mice.Parasitology research · 2014Article
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3 authors.
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Abstract
The emergence of resistance against most of the drugs in current use against malaria has aggravated the disease burden in endemic regions. Several plants species have been used for treatment of malaria in traditional/cultural health systems. Bergenia ciliata, used traditionally for treatment of fever by local communities in the Himalayan Region, was evaluated for its plausible role as an antimalarial. Phytochemical screening of the ethanolic leaf extract of B. ciliata (ELEBC) revealed the presence of phenols, flavonoids, steroids and diterpenes. The extract showed good in vitro antiplasmodial activity, with an IC50 <10 μg/ml. Acute toxicity of the extract was observed to be >5 g/kg, which is considered toxicologically safe for oral administration. When tested in vivo, different concentrations of the extract (250 to 1,000 mg/kg) exhibited considerable chemosuppression on day 7, in a dose-dependent manner. Maximum chemosuppression was observed to be 87.50% at 1,000 mg/kg. Administration of ELEBC (750 and 1,000 mg/kg) significantly (p < 0.0005) enhanced the mean survival time of mice in comparison to infected control, which exhibited a mean survival time of 8.6 ± 1.5 days. Study reports presence of considerable in vitro and in vivo antimalarial activity in ethanolic leaf extract of B. ciliata for first time. Hence, the ethnopharmacological usage of the plant for treating fever is confirmed with experimental evidence.
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