ArticleBriefings in functional genomics2013
Functional genomics of Plasmodium falciparum using metabolic modelling and analysis.
Article in Briefings in functional genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Comparative chemical genomics inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics.Molecular systems biology · 2021Article
- Vitamin and cofactor acquisition in apicomplexans: SynthesisThe Journal of biological chemistry · 2020Review
- Plasmodium genomics: an approach for learning about and ending human malaria.Parasitology research · 2019Review
- Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance.BMC genomics · 2017Article
- Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks.PLoS computational biology · 2017Article
- Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis.PLoS computational biology · 2015Article
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Authors and funding
4 authors.
Funding
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Abstract
Plasmodium falciparum is an obligate intracellular parasite and the leading cause of severe malaria responsible for tremendous morbidity and mortality particularly in sub-Saharan Africa. Successful completion of the P. falciparum genome sequencing project in 2002 provided a comprehensive foundation for functional genomic studies on this pathogen in the following decade. Over this period, a large spectrum of experimental approaches has been deployed to improve and expand the scope of functionally annotated genes. Meanwhile, rapidly evolving methods of systems biology have also begun to contribute to a more global understanding of various aspects of the biology and pathogenesis of malaria. Herein we provide an overview on metabolic modelling, which has the capability to integrate information from functional genomics studies in P. falciparum and guide future malaria research efforts towards the identification of novel candidate drug targets.
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