Evidence map›Paper›PMID 23793025›Full record

SynthesisNature genetics2013

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Verneri Anttila, Bendik S Winsvold, Padhraig Gormley, Tobias Kurth, Francesco Bettella, George McMahon, Mikko Kallela, Rainer Malik, Boukje de Vries, Gisela Terwindt and 87 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed, 22 pooled it
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

203 citing papers in PubMed, 22 syntheses or guidelines pooled it, 412 citations in OpenAlex.

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  3. What does a migraine aura look like?-A systematic review.The journal of headache and pain · 2025
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143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

97 authors at 20 institutions in 12 countries.

Verneri Anttila *Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Bendik S Winsvold *Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Padhraig GormleyWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Tobias KurthINSERM Unit 708 - Neuroepidemiology, F-33000 Bordeaux, France.
Francesco BettelladeCODE genetics, Reykjavik, Iceland.
George McMahonMRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Mikko KallelaDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Rainer MalikInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.
Boukje de VriesDepartment of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Gisela TerwindtDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Sarah E MedlandQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
Unda TodtInstitute of Human Genetics, University of Ulm, Ulm, Germany.
Wendy L McArdleMRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Lydia QuayeDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Markku KoiranenInstitute of Health Sciences, University of Oulu, Oulu, Finland.
M Arfan IkramGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
Anine H StamDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Lannie LigthartDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Juho WedenojaDepartment of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
Ian DunhamEuropean Bioinformatics Insitute, Wellcome Trust Genome Campus, Cambridge, UK.
Benjamin M NealeAnalytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Priit PaltaWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Eija HamalainenWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Markus SchürksDepartment of Neurology, University Hospital Essen, Essen, Germany.
Lynda M RoseDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Julie E BuringDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Paul M RidkerDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Stacy SteinbergdeCODE genetics, Reykjavik, Iceland.
Hreinn StefanssondeCODE genetics, Reykjavik, Iceland.
Finnbogi JakobssonDepartment of Neurology, Landspitali University Hospital, Reykjavik, Iceland.
Debbie A LawlorMRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
David M EvansMRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Susan M RingMRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Markus FärkkiläDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Ville ArttoDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Mari A KaunistoInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Tobias FreilingerInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.
Jean SchoenenHeadache Research Unit, Department of Neurology and Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA)-Neurosciences, Liège University, Liège, Belgium.
Rune R FrantsDepartment of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Nadine PelzerDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Claudia M WellerDepartment of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Ronald ZielmanDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Grant W MontgomeryQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
Nicholas G MartinQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
Guntram BorckInstitute of Human Genetics, University of Ulm, Ulm, Germany.
Hartmut GöbelKiel Pain and Headache Center, Kiel, Germany.
Axel HeinzeKiel Pain and Headache Center, Kiel, Germany.
Katja Heinze-KuhnKiel Pain and Headache Center, Kiel, Germany.
Frances M K WilliamsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Anna-Liisa HartikainenDepartment of Clinical Sciences/Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland.
Anneli PoutaInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Joyce van den EndeGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Albert HofmanGenetic Epidemiology Unit, Department of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jouke-Jan HottengaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Jacqueline M VinkDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Kauko HeikkiläDepartment of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
Michael AlexanderDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Bertram Muller-MyhsokMax Planck Institute of Psychiatry, Munich, Germany.
Stefan SchreiberDepartment of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Center Munich, Neuherberg, Germany.
Heinz Erich WichmannInstitut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München, Munich, Germany.
Arpo AromaaNational Institute for Health and Welfare, Helsinki, Finland.
Johan G ErikssonFolkhälsan Research Center, Helsinki, Finland.
Bryan TraynorLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Daniah TrabzuniDepartment of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
North American Brain Expression Consortium
UK Brain Expression Consortium
Elizabeth RossinAnalytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kasper LageAnalytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Suzanne B R JacobsProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
J Raphael GibbsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Ewan BirneyEuropean Bioinformatics Insitute, Wellcome Trust Genome Campus, Cambridge, UK.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Brenda W PenninxDepartment of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Cornelia van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Turku, Finland.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College, London, UK.
John-Anker ZwartDepartment of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Lynn CherkasDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
David P StrachanDivision of Population Health Sciences and Education, St George's, University of London, London, UK.
Christian KubischInstitute of Human Genetics, University of Ulm, Ulm, Germany.
Michel D FerrariDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Arn M J M van den MaagdenbergDepartment of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Martin DichgansInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.
Maija WessmanInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
George Davey SmithMRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Kari StefanssondeCODE genetics, Reykjavik, Iceland.
Mark J DalyAnalytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dale R NyholtQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
Daniel ChasmanDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Aarno PalotieWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Leiden University Medical Center · NLUniversity of Helsinki · FIUniversity of Bristol · GBdeCODE Genetics (Iceland) · ISErasmus University Rotterdam · NLFinnish Institute for Health and Welfare · FIBrigham and Women's Hospital · USClinical Research Center Kiel · DEHelsinki University Hospital · FIKing's College London · GBLeiden University · NLLudwig-Maximilians-Universität München · DEQIMR Berghofer Medical Research Institute · AUUniversität Ulm · DEErasmus MC · NLHarvard University · USMassachusetts General Hospital · USUniversity College London · GBWashington University in St. Louis · USBroad Institute · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
GENE-ENVIRONMENT INTERPLAY IN ALCOHOLISMK05AA017688 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2008 to 2017
$1.9M
Intramural NIH HHS Z01 AG000949Medical Research Council G0802462Medical Research Council G1001799Medical Research Council G9815508Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12013/5NIAAA NIH HHS K05 AA017688NIGMS NIH HHS T32 GM007753Wellcome Trust 089062Wellcome Trust 092731
6 · The paper itself

Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

Indexed as

Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyCerebellumComputational BiologyFrontal LobeHumansMigraine DisordersPolymorphism, Single NucleotideQuantitative Trait Loci

Identifiers

PMID23793025
PMCPMC4041123
OpenAlexW2136453726

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.