ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Altered ventricular torsion and transmural patterns of myocyte relaxation precede heart failure in aging F344 rats.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Sex- and age-dependent susceptibility to ventricular arrhythmias in the rat heart ex vivo.Scientific reports · 2024Article
- Biventricular intraventricular mechanical and electrical dyssynchrony in pulmonary arterial hypertension.Heliyon · 2024Article
- Multiscale characterization of left ventricle active behavior in the mouse.Acta biomaterialia · 2023Article
- Effects of Aging on Cardiac Oxidative Stress and Transcriptional Changes in Pathways of Reactive Oxygen Species Generation and Clearance.Journal of the American Heart Association · 2021Article
- Homogeneous 2D and 3D alignment of cardiomyocyte in dilated cardiomyopathy revealed by intravital heart imaging.Scientific reports · 2021Article
- Fast-relaxing cardiomyocytes exert a dominant role in the relaxation behavior of heterogeneous myocardium.Archives of biochemistry and biophysics · 2021Article
- The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases.Life (Basel, Switzerland) · 2021Review
- Cardiac MRI Assessment of Mouse Myocardial Infarction and Regeneration.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics.Journal of molecular and cellular cardiology · 2020Article
- Membrane stabilizer Poloxamer 188 improves yield of primary isolated rat cardiomyocytes without impairing function.Physiological reports · 2020Article
- Diverse relaxation rates exist among rat cardiomyocytes isolated from a single myocardial region.The Journal of physiology · 2019Article
- Voltage dependence of the CaMolecular and cellular biochemistry · 2018Article
- Skeletal myosin binding protein-C isoforms regulate thin filament activity in a CaScientific reports · 2018Article
- Regional quantification of myocardial mechanics in rat using 3D cine DENSE cardiovascular magnetic resonance.NMR in biomedicine · 2017Article
- Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload.Progress in biophysics and molecular biology · 2016Review
- Normal age-related changes in left ventricular function: Role of afterload and subendocardial dysfunction.International journal of cardiology · 2016Article
- Acute Optogenetic Modulation of Cardiac Twitch Dynamics Explored Through Modeling.Journal of biomechanical engineering · 2016Article
- Computational Investigation of Transmural Differences in Left Ventricular Contractility.Journal of biomechanical engineering · 2016Article
- Mitochondria and oxidative stress in heart aging.Age (Dordrecht, Netherlands) · 2016Review
- A Protocol for Collecting Human Cardiac Tissue for Research.The VAD journal : the journal of mechanical assisted circulation and heart failure · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this study was to identify and explain changes in ventricular and cellular function that contribute to aging-associated cardiovascular disease in aging F344 rats. Three groups of female F344 rats, aged 6, 18, and 22 mo, were studied. Echocardiographic measurements in isoflurane-anesthetized animals showed an increase in peak left ventricular torsion between the 6- and the 18-mo-old groups that was partially reversed in the 22-mo-old animals (P < 0.05). Epicardial, midmyocardial, and endocardial myocytes were subsequently isolated from the left ventricles of each group of rats. Unloaded sarcomere shortening and Ca(2+) transients were then measured in these cells (n = >75 cells for each of the nine age-region groups). The decay time of the Ca(2+) transient and the time required for 50% length relaxation both increased with age but not uniformly across the three regions (P < 0.02). Further analysis revealed a significant shift in the transmural distribution of these properties between 18 and 22 mo of age, with the largest changes occurring in epicardial myocytes. Computational modeling suggested that these changes were due in part to slower Ca(2+) dissociation from troponin in aging epicardial myocytes. Subsequent biochemical assays revealed a >50% reduction in troponin I phosphoprotein content in 22-mo-old epicardium relative to the other regions. These data suggest that between 18 and 22 mo of age (before the onset of heart failure), F344 rats display epicardial-specific myofilament-level modifications that 1) break from the progression observed between 6 and 18 mo and 2) coincide with aberrant patterns of cardiac torsion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.