ArticleEnvironmental health perspectives2013
Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Association of arsenic with adverse pregnancy outcomes/infant mortality: a systematic review and meta-analysis.Environmental health perspectives · 2015Pooled it
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- Disentangling the role of selenium in antagonizing the toxicity of arsenic and cadmium.Archives of toxicology · 2025Review
- E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025Review
- Impact of homocysteine on acute ischemic stroke severity: possible role of aminothiols redox status.BMC neurology · 2024Article
- Evaluation of the Possible Protective Role of Nobiletin against Arsenic-Induced Liver Damage in Male Albino Rats.Toxics · 2023Article
- Calcium carbide-induced derangement of hematopoiesis and organ toxicity ameliorated by cyanocobalamin in a mouse model.Laboratory animal research · 2022Article
- Research for type 2 diabetes mellitus in endemic arsenism areas in central China: role of low level of arsenic exposure and KEAP1 rs11545829 polymorphism.Archives of toxicology · 2022Article
- Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica.International journal of environmental research and public health · 2022Article
- Association between body mass index and arsenic methylation in three studies of Bangladeshi adults and adolescents.Environment international · 2021Article
- Relationships among Inorganic Arsenic, Nutritional Status CpG Methylation and microRNAs: A Review of the Literature.Epigenetics insights · 2021Review
- In Vitro Mitigation of Arsenic-Induced Toxicity by Reduced Glutathione in Rat Pulp Cells.European endodontic journal · 2020Article
- Locus-Specific Differential DNA Methylation and Urinary Arsenic: An Epigenome-Wide Association Study in Blood among Adults with Low-to-Moderate Arsenic Exposure.Environmental health perspectives · 2020Article
- Influence of Iron on Cytotoxicity and Gene Expression Profiles Induced by Arsenic in HepG2 Cells.International journal of environmental research and public health · 2019Article
- A Review of Dietary (Phyto)Nutrients for Glutathione Support.Nutrients · 2019Review
- A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in Bangladesh.PLoS genetics · 2019Article
- Redox balance and DNA fragmentation in arsenic-exposed occupational workers from different industries of Pakistan.Environmental science and pollution research international · 2018Article
- Nutritional Influences on One-Carbon Metabolism: Effects on Arsenic Methylation and Toxicity.Annual review of nutrition · 2018Review
- Low levels of lead and glutathione markers of redox status in human blood.Environmental geochemistry and health · 2018Article
- Age-dependent oxidation of extracellular cysteine/cystine redox state (EFree radical biology & medicine · 2018Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn vitro and rodent studies have shown that arsenic (As) exposure can deplete glutathione (GSH) and induce oxidative stress. GSH is the primary intracellular antioxidant; it donates an electron to reactive oxygen species, thus producing glutathione disulfide (GSSG). Cysteine (Cys) and cystine (CySS) are the predominant thiol/disulfide redox couple found in human plasma. Arsenic, GSH, and Cys are linked in several ways: a) GSH is synthesized via the transsulfuration pathway, and Cys is the rate-limiting substrate; b) intermediates of the methionine cycle regulate both the transsulfuration pathway and As methylation; c) GSH serves as the electron donor for reduction of arsenate to arsenite; and d) As has a high affinity for sulfhydryl groups and therefore binds to GSH and Cys.
objectivesWe tested the hypothesis that As exposure is associated with decreases in GSH and Cys and increases in GSSG and CySS (i.e., a more oxidized environment).
methodsFor this cross-sectional study, the Folate and Oxidative Stress Study, we recruited a total of 378 participants from each of five water As concentration categories: < 10 (n = 76), 10-100 (n = 104), 101-200 (n = 86), 201-300 (n = 67), and > 300 µg/L (n = 45). Concentrations of GSH, GSSG, Cys, and CySS were measured using HPLC.
resultsAn interquartile range (IQR) increase in water As was negatively associated with blood GSH (mean change, -25.4 µmol/L; 95% CI: -45.3, -5.31) and plasma CySS (mean change, -3.00 µmol/L; 95% CI: -4.61, -1.40). We observed similar associations with urine and blood As. There were no significant associations between As exposure and blood GSSG or plasma Cys.
conclusionsThe observed associations are consistent with the hypothesis that As may influence concentrations of GSH and other nonprotein sulfhydryls through binding and irreversible loss in bile and/or possibly in urine.
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