Trial reportAmerican journal of hypertension2013
Relation of N-terminal pro-B-type natriuretic peptide with diastolic function in hypertensive heart disease.
Trial report in American journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Plasma Biomarkers Reflecting Profibrotic Processes in Heart Failure With a Preserved Ejection Fraction: Data From the Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction Study.Circulation. Heart failure · 2016Trial
- Comparison of Serum proBNP and Apelin Levels in Hypertensive Crisis Versus Controlled Hypertension: Impact of Opium Addiction Status.Addiction & health · 2025Article
- Association of Longitudinal Changes in NT-proBNP With Changes in Left Atrial Volume and Function: MESA.American journal of hypertension · 2021Article
- Association of Global Longitudinal Strain With Clinical Status and Mortality in Patients With Chronic Heart Failure.JAMA cardiology · 2021Observational
- The Mechanism Actions of Astragaloside IV Prevents the Progression of Hypertensive Heart Disease Based on Network Pharmacology and Experimental Pharmacology.Frontiers in pharmacology · 2021Article
- Left Ventricular Strain: A Reliable Predictor of Short-Term Outcomes in Patients with Anterior Wall Myocardial Infarction without Heart Failure.Advanced biomedical research · 2020Article
- Influence of age and sex on left ventricular diastolic strain analysis.The international journal of cardiovascular imaging · 2019Article
- Mechanisms, diagnosis, and treatment of heart failure with preserved ejection fraction and diastolic dysfunction.Expert review of cardiovascular therapy · 2018Review
- Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt/eNOS/NO pathway.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- The Relation Between Global Longitudinal Strain and Serum Natriuretic Peptide Is More Strict Than That Found Between the Latter and Left Ventricular Ejection Fraction: A Retrospective Study in Chronic Heart Failure.Journal of clinical medicine research · 2015Article
- Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure.BMC cardiovascular disorders · 2015Article
- Recent publications by ochsner authors: october 2013 - march 2014.Ochsner journal · 2014Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundElevated natriuretic peptide levels in asymptomatic individuals without heart failure are associated with increased risk of adverse cardiovascular outcomes and may reflect subclinical cardiac dysfunction.
methodsIn a sample of 313 asymptomatic individuals (51% women, mean age 61 years) with hypertension and diastolic dysfunction, we examined the association of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) with both conventional and advanced echocardiographic measures of systolic and diastolic function, including myocardial strain, using speckle-tracking-based analyses.
resultsIn univariate analyses, higher NT-proBNP was associated with greater left ventricular mass index (P = 0.003), left atrial volume index (P = 0.007), lateral E' velocity (P < 0.0001), E/E' ratio (P < 0.0001), peak global longitudinal systolic strain (P = 0.015), systolic strain rate (P = 0.021), and early diastolic strain rate (P < 0.0001). In multivariable analyses, NT-proBNP remained associated with measures of diastolic dysfunction, including lateral E' velocity (P = 0.013) and the E/E' ratio (P = 0.008). However, early diastolic strain rate was the echocardiographic parameter most strongly associated with NT-proBNP (P = 0.003).
conclusionsIn the setting of asymptomatic hypertensive heart disease and preserved ejection fraction, elevation in natriuretic peptide levels is predominantly associated with subclinical diastolic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.