Evidence map›Paper›PMID 23792220›Full record

ArticleNeuroImage2013

Bayesian scalar-on-image regression with application to association between intracranial DTI and cognitive outcomes.

Lei Huang, Jeff Goldsmith, Philip T Reiss, Daniel S Reich, Ciprian M Crainiceanu

Abstract read
In one paragraph

Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Identifying regions of interest in mammogram images.Statistical methods in medical research · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Methods for scalar-on-function regression.International statistical review = Revue internationale de statistique · 2017
    Article
  8. Article
  9. Article
  10. Bayesian Multiresolution Variable Selection for Ultra-High Dimensional Neuroimaging Data.IEEE/ACM transactions on computational biology and bioinformatics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei HuangDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: lehuang@jhsph.edu.
Jeff Goldsmith
Philip T Reiss
Daniel S Reich
Ciprian M Crainiceanu

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Statistical Methods for Multilevel Multivariate Functional StudiesR01NS060910 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Ciprian M Crainiceanu · 2009 to 2026
$8.3M
Statistical Methods for Mapping Human Brain DevelopmentR01MH095836 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REISS, PHILIP T · 2012 to 2016
$2.1M
Statistical methods for large and complex databases of ultra-high-dimensionalR01NS085211 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2013 to 2017
$1.8M
Intramural NIH HHSNIMH NIH HHS R01 MH095836NINDS NIH HHS R01 NS060910NINDS NIH HHS R01 NS085211
6 · The paper itself

Abstract

Diffusion tensor imaging (DTI) measures water diffusion within white matter, allowing for in vivo quantification of brain pathways. These pathways often subserve specific functions, and impairment of those functions is often associated with imaging abnormalities. As a method for predicting clinical disability from DTI images, we propose a hierarchical Bayesian "scalar-on-image" regression procedure. Our procedure introduces a latent binary map that estimates the locations of predictive voxels and penalizes the magnitude of effect sizes in these voxels, thereby resolving the ill-posed nature of the problem. By inducing a spatial prior structure, the procedure yields a sparse association map that also maintains spatial continuity of predictive regions. The method is demonstrated on a simulation study and on a study of association between fractional anisotropy and cognitive disability in a cross-sectional sample of 135 multiple sclerosis patients.

Indexed as

AdultAgedAlgorithmsBayes TheoremBrainCognitionCognition DisordersComputer SimulationDiffusion Tensor ImagingFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedModels, NeurologicalBinary Markov random fieldDiffusion tensor imagingIsing priorMultiple sclerosis

Identifiers

PMID23792220
PMCPMC3815966

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.