ArticleBehavioural processes2013
Sex-specific effect of the anabolic steroid, 17α-methyltestosterone, on inhibitory avoidance learning in periadolescent rats.
Article in Behavioural processes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- In-vitro pharmacological and cytotoxic evaluation of genipin-crosslinked human serum albumin nanoparticles loaded with methyltestosterone in MCF-7 breast cancer cells.BMC pharmacology & toxicology · 2026Article
- Chronic high-dose testosterone impairs economic decision making, but has no effect on memory in male rats.Behavioural processes · 2024Article
- Anabolic androgenic steroid abuse in the United Kingdom: An update.British journal of pharmacology · 2020Review
- Neonatal Dexamethasone Treatment Suppresses Hippocampal Estrogen Receptor α Expression in Adolescent Female Rats.Molecular neurobiology · 2019Article
- Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods.Developmental cognitive neuroscience · 2018Review
- Article
- Anabolic/androgenic steroid administration during adolescence and adulthood differentially modulates aggression and anxiety.Hormones and behavior · 2015Article
- Influence of contextual exposure on memory strength and precision for inhibitory avoidance in male and female rats.Learning & memory (Cold Spring Harbor, N.Y.)Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The illicit use of anabolic androgenic steroids (AAS) has gained popularity among adolescents in the last decade. However, although it is known that exposure to AAS impairs cognition in adult animal models, the cognitive effects during adolescence remain undetermined. An inhibitory avoidance task (IAT) was used to assess the effect of AAS (17α-methyltestosterone; 17α-meT--7.5 mg/kg) in male and female periadolescent rats. A single injection of 17α-meT immediately before the footshock produced significant impairment of inhibitory avoidance learning in males but not females. Generalized anxiety, locomotion, and risk assessment behaviors (RAB) were not affected. Our results show that exposure to a single pharmacological dose of 17α-meT during periadolescence exerts sex-specific cognitive effects without affecting anxiety. Thus, disruption of the hormonal milieu during this early developmental period might have negative impact on learning and memory.
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