ArticlePain2013
Sex differences in emotion-related cognitive processes in irritable bowel syndrome and healthy control subjects.
Article in Pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02358486 (Effect and Mechanism of Acupuncture on Patients With Functional Dyspepsia), which is not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect and Mechanism of Acupuncture on Patients With Functional Dyspepsia: a Protocol for a Randomized, Assessor-blind, Sham-controlled Trial
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- A systematic review of associations between functional connectivity, mood and cognition in patients with irritable bowel syndrome.Brain imaging and behavior · 2026Pooled it
- Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies.NeuroImage. Clinical · 2016Pooled it
- Trial
- Reduced Functional Connectivity Between the Hypothalamus and High-order Cortical Regions in Adolescent Patients With Irritable Bowel Syndrome.Journal of pediatric gastroenterology and nutrition · 2017Trial
- Phocaeicola vulgatus improves anxiety-like behavior by ameliorating amygdala neuroinflammation and the neurite impairment in IBS.Translational psychiatry · 2026Article
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- Sex-based associations between neighborhood disadvantage and brain-gut alterations in individuals with irritable bowel syndrome.Biology of sex differences · 2025Article
- Aberrant functional connectivity patterns in the pregenual anterior cingulate cortex and anterior midcingulate cortex of patients with irritable bowel syndrome accompanied by depressive symptoms.Brain imaging and behavior · 2025Article
- Exploration of TCM Comprehensive Treatment of Irritable Bowel Syndrome Based on Pathophysiological Mechanism.International journal of general medicine · 2025Review
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- Gut-Brain Axis: Focus on Sex Differences in Neuroinflammation.International journal of molecular sciences · 2024Review
- Review
- Gender differences in gastrointestinal, biopsychosocial and healthcare-seeking behaviors in Chinese patients with irritable bowel syndrome predominant with diarrhea.BMC gastroenterology · 2024Article
- The neurobiology of irritable bowel syndrome.Molecular psychiatry · 2023Review
- A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits.Neuropharmacology · 2023Review
- Alterations in functional connectivity and interactions in resting-state networks in female patients with functional constipation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Functional Neuroimaging in Irritable Bowel Syndrome: A Systematic Review Highlights Common Brain Alterations With Functional Movement Disorders.Journal of neurogastroenterology and motility · 2022Review
- Current Understanding of the Involvement of the Insular Cortex in Neuropathic Pain: A Narrative Review.International journal of molecular sciences · 2021Review
- Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study.Brain imaging and behavior · 2020Article
- Importance of trauma-related fear in patients with irritable bowel syndrome and early adverse life events.Neurogastroenterology and motility · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Greater responsiveness of emotional arousal circuits in relation to delivered visceral pain has been implicated as underlying central pain amplification in irritable bowel syndrome (IBS), with female subjects showing greater responses than male subjects. Functional magnetic resonance imaging was used to measure neural responses to an emotion recognition paradigm, using faces expressing negative emotions (fear and anger). Sex and disease differences in the connectivity of affective and modulatory cortical circuits were studied in 47 IBS (27 premenopausal female subjects) and 67 healthy control subjects (HCs; 38 premenopausal female subjects). Male subjects (IBS+HC) showed greater overall brain responses to stimuli than female subjects in prefrontal cortex, insula, and amygdala. Effective connectivity analyses identified major sex- and disease-related differences in the functioning of brain networks related to prefrontal regions, cingulate, insula, and amygdala. Male subjects had stronger connectivity between anterior cingulate subregions, amygdala, and insula, whereas female subjects had stronger connectivity to and from the prefrontal modulatory regions (medial/dorsolateral cortex). Male IBS subjects demonstrate greater engagement of cortical and affect-related brain circuitry compared to male control subjects and female subjects, when viewing faces depicting emotions previously shown to elicit greater behavioral and brain responses in male subjects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.