ArticleJournal of structural biology2013
Water in the formation of biogenic minerals: peeling away the hydration layers.
Article in Journal of structural biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Engineering macromolecular crowding-driven amyloid-mineral hybrid scaffolds for enhanced bone regeneration.Bioactive materials · 2026Article
- Hyperpolarized NMR Combined with Quantum Mechanical Simulations Reveal Atomistic Structures of Calcium Phosphate Prenucleation Clusters.Analytical chemistry · 2025Article
- Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity.Current osteoporosis reports · 2025Review
- Short-lived calcium carbonate precursors observed in situ via Bullet-dynamic nuclear polarization.Communications chemistry · 2024Article
- Observation of Transient Prenucleation Species of Calcium Carbonate by DNP-Enhanced NMR.The journal of physical chemistry letters · 2024Article
- From salt water to bioceramics: Mimic nature through pressure-controlled hydration and crystallization.Science advances · 2024Article
- A bicarbonate-rich liquid condensed phase in non-saturated solutions in the absence of divalent cations.Frontiers in bioengineering and biotechnology · 2024Article
- Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass.International journal of molecular sciences · 2021Article
- Phase-Field Modeling of Biomineralization in Mollusks and Corals: Microstructure vs Formation Mechanism.JACS Au · 2021Article
- In Vitro Mineralization of Collagen.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Assessing the Onset of Calcium Phosphate Nucleation by Hyperpolarized Real-Time NMR.Analytical chemistry · 2020Article
- First evidence of octacalcium phosphate@osteocalcin nanocomplex as skeletal bone component directing collagen triple-helix nanofibril mineralization.Scientific reports · 2018Article
- Green Rust: The Simple Organizing 'Seed' of All Life?Life (Basel, Switzerland) · 2018Review
- The Mineral-Collagen Interface in Bone.Calcified tissue international · 2015Review
- Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers.Scientific reports · 2015Article
- A review of the bioactivity of hydraulic calcium silicate cements.Journal of dentistry · 2014Review
- Adopting the principles of collagen biomineralization for intrafibrillar infiltration of yttria-stabilized zirconia into three-dimensional collagen scaffolds.Advanced functional materials · 2014Article
- The role of acidic phosphoproteins in biomineralization.Connective tissue researchReview
- Lens capsule as a model to study type IV collagen.Connective tissue researchReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Minerals of biogenic origin form and crystallize from aqueous environments at ambient temperatures and pressures. The in vivo environment either intracellular or intercellular, contains many components that modulate both the activity of the ions which associate to form the mineral, as well as the activity and structure of the crowded water. Most of the studies about the mechanism of mineralization, that is, the detailed pathways by which the mineral ions proceed from solution to crystal state, have been carried out in relatively dilute solutions and clean solutions. These studies have considered both thermodynamic and kinetic controls. Most have not considered the water itself. Is the water a passive bystander, or is it intimately a participant in the mineral ion densification reaction? A wide range of experiments show that the mineralization pathways proceed through a series of densification stages with intermediates, such as a "dense liquid" phase and the prenucleation clusters that form within it. This is in contrast to the idea of a single step phase transition, but consistent with the Gibbs concept of discontinuous phase transitions from supersaturated mother liquor to crystal. Further changes in the water structure at every surface and interface during densification guides the free energy trajectory leading to the crystalline state. In vertebrates, mineralization takes place in a hydrated collagen matrix, thus water must be considered as a direct participant. Although different in detail, the crystallization of calcium phosphates, as apatite, and calcium carbonates, as calcite, are mechanistically identical from the viewpoint of water.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.