ArticleCurrent biology : CB2013
Polarity in migrating neurons is related to a mechanism analogous to cytokinesis.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Did axons evolve by activating cytokinesis during interphase? A hypothesis on the origin of neurons.Molecular biology of the cell · 2025Review
- Article
- KIFC1 Regulates the Trajectory of Neuronal Migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The kinesin-like protein Pavarotti functions noncanonically to regulate actin dynamics.The Journal of cell biology · 2020Article
- Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity.Nature communications · 2020Article
- Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.Human molecular genetics · 2020Article
- A Peptide Link Between Human Cytomegalovirus Infection, Neuronal Migration, and Psychosis.Frontiers in psychiatry · 2020Article
- Review
- Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome.Frontiers in molecular neuroscience · 2019Article
- Article
- Sliding of centrosome-unattached microtubules defines key features of neuronal phenotype.The Journal of cell biology · 2016Article
- Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actin Related Cytoskeletal Reorganization.International journal of biological sciences · 2016Article
- Soy glyceollins regulate transcript abundance in the female mouse brain.Functional & integrative genomics · 2015Article
- Pavarotti/MKLP1 regulates microtubule sliding and neurite outgrowth in Drosophila neurons.Current biology : CB · 2015Article
- Regulating Rac in the nervous system: molecular function and disease implication of Rac GEFs and GAPs.BioMed research international · 2015Review
- Molecules and mechanisms that regulate multipolar migration in the intermediate zone.Frontiers in cellular neuroscience · 2014Review
- Capture of microtubule plus-ends at the actin cortex promotes axophilic neuronal migration by enhancing microtubule tension in the leading process.Frontiers in cellular neuroscience · 2014Article
- Neuronal migration re-purposes mechanisms of cytokinesis.Cell cycle (Georgetown, Tex.) · 2013Article
- Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Migrating neurons are bipolar, with a leading process and a trailing process [1]. The proximal region of the leading process displays a concentration of F-actin that contributes to the advance of the soma and the centrosome [2-7]. Here, we show that kinesin-6, a microtubule-based motor protein best known for its role in cytokinesis, also concentrates in this region. Depletion of kinesin-6 results in multipolar neurons that either are stationary or continuously change their direction of movement. In such neurons, F-actin no longer concentrates in a single process. During cytokinesis, kinesin-6 forms a complex with a Rho-family GTPase-activating protein called MgcRacGAP to signal to the actin cytoskeleton so that cortical movements are concentrated in the cleavage furrow [8-13]. During neuronal migration, MgcRacGap also concentrates in the proximal region of the leading process, and inhibition of its activity results in a phenotype similar to kinesin-6 depletion. We conclude that neuronal migration utilizes a cytoskeletal pathway analogous to cytokinesis, with kinesin-6 signaling through MgcRacGap to the actin cytoskeleton to constrain process number and restrict protrusive activity to a single leading process, thus resulting in a bipolar neuron able to move in a directed fashion.
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