ArticleActa biomaterialia2013
Bio-inspired stable antimicrobial peptide coatings for dental applications.
Article in Acta biomaterialia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.Frontiers in cellular and infection microbiology · 2021Pooled it
- IG-13-1 peptide-loaded chitosan nanoparticles in dental adhesives: Physicomechanical, and biological performance.Journal of Taibah University Medical Sciences · 2026Article
- Nature-inspired biomaterial innovations to counter medical device-associated infections.Biomaterials science · 2026Review
- Dual-Function Antimicrobial Peptides as a Prospective Strategy Against Peri-Implantitis: Bridging Cutaneous Wound Healing and the Peri-Implant Soft-Tissue Seal.Medicina (Kaunas, Lithuania) · 2026Review
- Biomimetic Surface Engineering Strategies for Enhanced Osseointegration and Peri-Implant Bone Regeneration: A Systematic Review.Biomimetics (Basel, Switzerland) · 2026Review
- Exploring immobilization strategies of antimicrobial peptides onto MAO-treated titanium to fight MRSA colonization and preserve osteogenic activity.Materials today. Bio · 2026Article
- Smart biomaterials in restorative dentistry: Recent advances and future perspectives.Materials today. Bio · 2025Review
- Periprosthetic joint infection after arthroplasty: advances and future prospects.Journal of orthopaedic surgery and research · 2025Review
- A deformable SIS/HA composite hydrogel coaxial scaffold promotes alveolar bone regeneration after tooth extraction.Bioactive materials · 2025Article
- Enhancing implant surfaces: mechanical stability and cytocompatibility of DNase I coatings deposited by alternating current electrophoretic deposition.Frontiers in bioengineering and biotechnology · 2025Article
- Biomaterials science and surface engineering strategies for dental peri-implantitis management.Military Medical Research · 2024Review
- Article
- Machine learning enabled design features of antimicrobial peptides selectively targeting peri-implant disease progression.Frontiers in dental medicine · 2024Article
- Biomimetic Coatings in Implant Dentistry: A Quick Update.Journal of functional biomaterials · 2023Review
- Chemoselective Coatings of GL13K Antimicrobial Peptides for Dental Implants.Pharmaceutics · 2023Article
- Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation.Bioactive materials · 2023Review
- Smart dental materials for antimicrobial applications.Bioactive materials · 2023Article
- Complex Networks Analyses of Antibiofilm Peptides: An Emerging Tool for Next-Generation Antimicrobials' Discovery.Antibiotics (Basel, Switzerland) · 2023Article
- Improving Biocompatibility for Next Generation of Metallic Implants.Progress in materials science · 2023Article
- Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We developed a novel titanium coating that has applications for preventing infection-related implant failures in dentistry and orthopedics. The coating incorporates an antimicrobial peptide, GL13K, derived from parotid secretory protein, which has been previously shown to be bactericidal and bacteriostatic in solution. We characterized the resulting physicochemical properties, resistance to degradation, activity against Porphyromonas gingivalis and in vitro cytocompatibility. Porphyromonas gingivalis is a pathogen associated with dental peri-implantitis, an inflammatory response to bacteria resulting in bone loss and implant failure. Our surface modifications obtained a homogeneous, highly hydrophobic and strongly anchored GL13K coating that was resistant to mechanical, thermochemical and enzymatic degradation. The GL13K coatings had a bactericidal effect and thus significantly reduced the number of viable bacteria compared to control surfaces. Finally, adequate proliferation of osteoblasts and human gingival fibroblasts demonstrated the GL13K coating's cytocompatibility. The robustness, antimicrobial activity and cytocompatibility of GL13K-biofunctionalized titanium make it a promising candidate for sustained inhibition of bacterial biofilm growth. This surface chemistry provides a basis for development of multifunctional bioactive surfaces to reduce patient morbidities and improve long-term clinical efficacy of metallic dental and orthopedic implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.