ArticleNeuron2013
GABAergic lateral interactions tune the early stages of visual processing in Drosophila.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- A recurrent neural circuit in Drosophila temporally sharpens visual inputs.Current biology : CB · 2025Article
- Adaptation to visual sparsity enhances responses to isolated stimuli.Current biology : CB · 2024Article
- A recurrent neural circuit inbioRxiv : the preprint server for biology · 2024Article
- Transgenic line for characterizing GABA-receptor expression to study the neural basis of olfaction in the yellow-fever mosquito.Frontiers in physiology · 2024Article
- Article
- Article
- Populations of local direction-selective cells encode global motion patterns generated by self-motion.Science advances · 2022Article
- Mathematical study of neural feedback roles in small target motion detection.Frontiers in neurorobotics · 2022Article
- Predicting individual neuron responses with anatomically constrained task optimization.Current biology : CB · 2021Article
- Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies.The Journal of comparative neurology · 2020Article
- Serotonergic modulation of visual neurons in Drosophila melanogaster.PLoS genetics · 2020Article
- Object-Displacement-Sensitive Visual Neurons Drive Freezing in Drosophila.Current biology : CB · 2020Article
- Seeing Natural Images through the Eye of a Fly with Remote Focusing Two-Photon Microscopy.iScience · 2020Article
- Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- A minimal synaptic model for direction selective neurons in Drosophila.Journal of vision · 2020Article
- Heterogeneous Temporal Contrast Adaptation in Drosophila Direction-Selective Circuits.Current biology : CB · 2020Article
- Article
- ON selectivity in theeLife · 2019Article
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5 authors.
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Abstract
Early stages of visual processing must capture complex, dynamic inputs. While peripheral neurons often implement efficient encoding by exploiting natural stimulus statistics, downstream neurons are specialized to extract behaviorally relevant features. How do these specializations arise? We use two-photon imaging in Drosophila to characterize a first-order interneuron, L2, that provides input to a pathway specialized for detecting moving dark edges. GABAergic interactions, mediated in part presynaptically, create an antagonistic and anisotropic center-surround receptive field. This receptive field is spatiotemporally coupled, applying differential temporal processing to large and small dark objects, achieving significant specialization. GABAergic circuits also mediate OFF responses and balance these with responses to ON stimuli. Remarkably, the functional properties of L2 are strikingly similar to those of bipolar cells, yet emerge through different molecular and circuit mechanisms. Thus, evolution appears to have converged on a common strategy for processing visual information at the first synapse.
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