ArticleAmerican journal of human genetics2013
Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk.
Article in American journal of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.Nature communications · 2015Pooled it
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- Prediagnostic serum sCD27 and sCD30 in serial samples and risks of non-Hodgkin lymphoma subtypes.International journal of cancer · 2020Article
- Follicular lymphoma polygenic risk score is associated with increased disease risk but improved overall survival among women in a population based case-control in Los Angeles County California.Cancer epidemiology · 2020Article
- Association Analysis of the MHC in Lupus Nephritis.Journal of the American Society of Nephrology : JASN · 2017Article
- Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.Scientific reports · 2017Article
- NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study.PloS one · 2017Article
- Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Nature reviews. Genetics · 2016Review
- Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Nature genetics · 2015Article
- Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci.American journal of epidemiology · 2015Review
- Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.American journal of human genetics · 2014Article
- Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.American journal of human genetics · 2014Article
- Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression.Genes and immunity · 2014Article
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Authors and funding
21 authors at 12 institutions in 5 countries.
Funding
Abstract
Non-Hodgkin lymphoma represents a diverse group of blood malignancies, of which follicular lymphoma (FL) is a common subtype. Previous genome-wide association studies (GWASs) have identified in the human leukocyte antigen (HLA) class II region multiple independent SNPs that are significantly associated with FL risk. To dissect these signals and determine whether coding variants in HLA genes are responsible for the associations, we conducted imputation, HLA typing, and sequencing in three independent populations for a total of 689 cases and 2,446 controls. We identified a hexa-allelic amino acid polymorphism at position 13 of the HLA-DR beta chain that showed the strongest association with FL within the major histocompatibility complex (MHC) region (multiallelic p = 2.3 × 10⁻¹⁵). Out of six possible amino acids that occurred at that position within the population, we classified two as high risk (Tyr and Phe), two as low risk (Ser and Arg), and two as moderate risk (His and Gly). There was a 4.2-fold difference in risk (95% confidence interval = 2.9-6.1) between subjects carrying two alleles encoding high-risk amino acids and those carrying two alleles encoding low-risk amino acids (p = 1.01 × 10⁻¹⁴). This coding variant might explain the complex SNP associations identified by GWASs and suggests a common HLA-DR antigen-driven mechanism for the pathogenesis of FL and rheumatoid arthritis.
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