ArticleJournal of biomechanics2013
Tissue-engineered articular cartilage exhibits tension-compression nonlinearity reminiscent of the native cartilage.
Article in Journal of biomechanics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Equilibrium Mechanical Properties of the Nonhuman Primate Cervix.Journal of biomechanical engineering · 2024Article
- Optics-Free, In Situ Swelling Monitoring of Articular Cartilage with Graphene Strain Sensors.ACS biomaterials science & engineering · 2023Article
- The interplay between chondrocyte spheroids and mesenchymal stem cells boosts cartilage regeneration within a 3D natural-based hydrogel.Scientific reports · 2019Article
- Human chondrocyte migration behaviour to guide the development of engineered cartilage.Journal of tissue engineering and regenerative medicine · 2017Article
- Dynamic Mechanical Compression of Chondrocytes for Tissue Engineering: A Critical Review.Frontiers in bioengineering and biotechnology · 2017Review
- Nutrient Channels Aid the Growth of Articular Surface-Sized Engineered Cartilage Constructs.Tissue engineering. Part A · 2016Article
- High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties.Journal of biomechanics · 2016Article
- Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α.Tissue engineering. Part A · 2016Article
- A puzzle assembly strategy for fabrication of large engineered cartilage tissue constructs.Journal of biomechanics · 2016Article
- Anatomic Mesenchymal Stem Cell-Based Engineered Cartilage Constructs for Biologic Total Joint Replacement.Tissue engineering. Part A · 2016Article
- High intensity focused ultrasound as a tool for tissue engineering: Application to cartilage.Medical engineering & physics · 2016Article
- Long-term storage and preservation of tissue engineered articular cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Porous titanium bases for osteochondral tissue engineering.Acta biomaterialia · 2015Article
- Impact of guidance documents on translational large animal studies of cartilage repair.Science translational medicine · 2015Article
- Time and dose-dependent effects of chondroitinase ABC on growth of engineered cartilage.European cells & materials · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The tensile modulus of articular cartilage is much larger than its compressive modulus. This tension-compression nonlinearity enhances interstitial fluid pressurization and decreases the frictional coefficient. The current set of studies examines the tensile and compressive properties of cylindrical chondrocyte-seeded agarose constructs over different developmental stages through a novel method that combines osmotic loading, video microscopy, and uniaxial unconfined compression testing. This method was previously used to examine tension-compression nonlinearity in native cartilage. Engineered cartilage, cultured under free-swelling (FS) or dynamically loaded (DL) conditions, was tested in unconfined compression in hypertonic and hypotonic salt solutions. The apparent equilibrium modulus decreased with increasing salt concentration, indicating that increasing the bath solution osmolarity shielded the fixed charges within the tissue, shifting the measured moduli along the tension-compression curve and revealing the intrinsic properties of the tissue. With this method, we were able to measure the tensile (401±83kPa for FS and 678±473kPa for DL) and compressive (161±33kPa for FS and 348±203kPa for DL) moduli of the same engineered cartilage specimens. These moduli are comparable to values obtained from traditional methods, validating this technique for measuring the tensile and compressive properties of hydrogel-based constructs. This study shows that engineered cartilage exhibits tension-compression nonlinearity reminiscent of the native tissue, and that dynamic deformational loading can yield significantly higher tensile properties.
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