Evidence map›Paper›PMID 23790978›Full record

ArticlePsychiatry research2013

A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder.

Sara E Trace, Laura M Thornton, Jessica H Baker, Tammy L Root, Lauren E Janson, Paul Lichtenstein, Nancy L Pedersen, Cynthia M Bulik

Abstract readTwin Study
In one paragraph

Article in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. The current clinical approach to feeding and eating disorders aimed to increase personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Article
  2. Article
  3. Article
  4. Comorbidity between eating disorders and psychiatric disorders.The International journal of eating disorders · 2022
    Article
  5. Article
  6. Alcohol Use and Disordered Eating in a US Sample of Heterosexual and Sexual Minority Adolescents.Journal of the American Academy of Child and Adolescent Psychiatry · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders.European eating disorders review : the journal of the Eating Disorders Association · 2016
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Genetics and Epigenetics of Eating Disorders.Advances in genomics and genetics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara E TraceDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Laura M Thornton
Jessica H Baker
Tammy L Root
Lauren E Janson
Paul Lichtenstein
Nancy L Pedersen
Cynthia M Bulik

Funding

Optimizing Technology in the Treatment of Bulimia NervosaR01MH080065 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2008 to 2012
$3.2M
Enhancing Treatment for Adult Anorexia Nervosa with a Couple-Based ApproachR01MH093615 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAUCOM, DONALD H, BULIK, CYNTHIA M · 2012 to 2016
$3.1M
GENETIC &ENVIRONMENT DETERMINANTS OF SMOKING CESSATIONR01CA085739 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SULLIVAN, PATRICK F · 2001 to 2006
$3.1M
Postdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8M
Microarrays &Proteomics in MZ Twins Discordant for CFSR01AI056014 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2004 to 2006
$1.2M
Genetic and Environmental Contributions to Alcohol Use and Eating DisordersK01AA018719 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROOT, TAMMY · 2010 to 2011
$248k
NCI NIH HHS CA-085739NCI NIH HHS R01 CA085739NIAAA NIH HHS 1K01AA18719-01A1NIAAA NIH HHS K01 AA018719NIAID NIH HHS AI-056014NIAID NIH HHS R01 AI056014NIMH NIH HHS R01 MH080065NIMH NIH HHS R01 MH093615NIMH NIH HHS T32 MH076694NIMH NIH HHS T32MH076694
6 · The paper itself

Abstract

Bulimia nervosa (BN) and alcohol use disorder (AUD) frequently co-occur and may share genetic factors; however, the nature of their association is not fully understood. We assessed the extent to which the same genetic and environmental factors contribute to liability to BN and AUD. A bivariate structural equation model using a Cholesky decomposition was fit to data from 7241 women who participated in the Swedish Twin study of Adults: Genes and Environment. The proportion of variance accounted for by genetic and environmental factors for BN and AUD and the genetic and environmental correlations between these disorders were estimated. In the best-fitting model, the heritability estimates were 0.55 (95% CI: 0.37; 0.70) for BN and 0.62 (95% CI: 0.54; 0.70) for AUD. Unique environmental factors accounted for the remainder of variance for BN. The genetic correlation between BN and AUD was 0.23 (95% CI: 0.01; 0.44), and the correlation between the unique environmental factors for the two disorders was 0.35 (95% CI: 0.08; 0.61), suggesting moderate overlap in these factors. The findings from this investigation provide additional support that some of the same genetic factors may influence liability to both BN and AUD.

Indexed as

EnvironmentAdultAlcohol-Related DisordersBulimia NervosaChi-Square DistributionDiseases in TwinsFemaleHumansMiddle AgedModels, StatisticalRisk FactorsSwedenTwins, DizygoticTwins, MonozygoticYoung AdultBivariateComorbidityTwin study

Identifiers

PMID23790978
PMCPMC3736835

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.