ArticleBMB reports2013
Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor.
Article in BMB reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Effects of high intensity interval vs. low intensity continuous training on LXRβ, ABCG5 and ABCG8 genes expression in male wistar rats.ARYA atherosclerosis · 2024Article
- Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics.Signal transduction and targeted therapy · 2022Review
- The Susceptibility to Diet-Induced Atherosclerosis Is Exacerbated with Aging in C57B1/6 Mice.Biomedicines · 2021Article
- Article
- HDL particle size is increased and HDL-cholesterol efflux is enhanced in type 1 diabetes: a cross-sectional study.Diabetologia · 2021Article
- The effect of ursodeoxycholic acid on the relative expression of the lipid metabolism genes in mouse cholesterol gallstone models.Lipids in health and disease · 2020Article
- Mechanisms and regulation of cholesterol homeostasis.Nature reviews. Molecular cell biology · 2020Review
- Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations.Biological procedures online · 2020Article
- Genes Potentially Associated with Familial Hypercholesterolemia.Biomolecules · 2019Review
- ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion.Biochemical Society transactions · 2019Review
- ABCG5 and ABCG8: more than a defense against xenosterols.Journal of lipid research · 2018Review
- Article
- GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice.Metabolism: clinical and experimental · 2015Article
- Transcriptional regulation of Niemann-Pick C1-like 1 gene by liver receptor homolog-1.BMB reports · 2015Article
- Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice.Scientific reports · 2015Article
- Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development.The Journal of physiology · 2015Article
- AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions.Journal of ginseng research · 2015Article
- Nuclear localization signal domain of HDAC3 is necessary and sufficient for the expression regulation of MDR1.BMB reports · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ATP-binding cassette transporters ABCG5 and ABCG8 form heterodimers that limit absorption of dietary sterols in the intestine and promote cholesterol elimination from the body through hepatobiliary secretion. To identify cis-regulatory elements of the two genes, we have cloned and analyzed twenty-three evolutionary conserved region (ECR) fragments using the CMV-luciferase reporter system in HepG2 cells. Two ECRs were found to be responsive to the Liver-X-Receptor (LXR). Through elaborate deletion studies, regions containing putative LXREs were identified and the binding of LXRα was demonstrated by EMSA and ChIP assay. When the LXREs were inserted upstream of the intergenic promoter, synergistic activation by LXRα/RXRα in combination with GATA4, HNF4α, and LRH-1, which had been shown to bind to the intergenic region, was observed. In conclusion, we have identified two LXREs in ABCG5/ABCG8 genes for the first time and propose that these LXREs, especially in the ECR20, play major roles in regulating these genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.