ArticleNeuron2013
SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 58 citations in OpenAlex.
- Further characterization of the BRSK2-associated neurodevelopmental disorder.European journal of human genetics : EJHG · 2026Article
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- Haploinsufficiency of brain-specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders.Epilepsia · 2025Article
- The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions.Nature communications · 2024Article
- BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes.Journal of molecular cell biology · 2023Article
- Dynamic Regulation ofInternational journal of molecular sciences · 2023Article
- Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations.Cell reports · 2023Article
- Liver Kinase B1 Functions as a Regulator for Neural Development and a Therapeutic Target for Neural Repair.Cells · 2022Review
- An NT-3-releasing bioscaffold supports the formation ofBioactive materials · 2021Article
- LKB1 and AMPK instruct cone nuclear position to modify visual function.Cell reports · 2021Article
- Regulation of axonal morphogenesis by the mitochondrial protein Efhd1.Life science alliance · 2020Article
- LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina.eLife · 2020Article
- Impaired experience-dependent maternal care in presynaptic active zone protein CAST-deficient dams.Scientific reports · 2020Article
- SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Roles of axon guidance molecules in neuronal wiring in the developing spinal cord.Nature reviews. Neuroscience · 2019Review
- Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes.NPJ genomic medicine · 2019Article
- Stroke Recovery in Rats after 24-Hour-Delayed Intramuscular Neurotrophin-3 Infusion.Annals of neurology · 2019Article
- SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells.Endocrinology · 2018Article
- Molecular mechanisms underlying monosynaptic sensory-motor circuit development in the spinal cord.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
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3 authors at 1 institution in 1 country.
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Abstract
Extrinsic cues activate intrinsic signaling mechanisms to pattern neuronal shape and connectivity. We showed previously that three cytoplasmic Ser/Thr kinases, LKB1, SAD-A, and SAD-B, control early axon-dendrite polarization in forebrain neurons. Here, we assess their role in other neuronal types. We found that all three kinases are dispensable for axon formation outside of the cortex but that SAD kinases are required for formation of central axonal arbors by subsets of sensory neurons. The requirement for SAD kinases is most prominent in NT-3 dependent neurons. SAD kinases transduce NT-3 signals in two ways through distinct pathways. First, sustained NT-3/TrkC signaling increases SAD protein levels. Second, short-duration NT-3/TrkC signals transiently activate SADs by inducing dephosphorylation of C-terminal domains, thereby allowing activating phosphorylation of the kinase domain. We propose that SAD kinases integrate long- and short-duration signals from extrinsic cues to sculpt axon arbors within the CNS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.